DAPTA

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Cat.No. 2423 - DAPTA | D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2 | CAS No. 106362-34-9
Description: Chemokine receptor 5 (CCR5) antagonist
Alternative Names: D-Ala-peptide T-amide
Datasheet
Citations
Reviews
Literature

Biological Activity

Chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.

Technical Data

M. Wt 856.89
Formula C35H56N10O15
Sequence ASTTTNYT

(Modifications: Ala-1 = D-Ala, Thr-8 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 106362-34-9
PubChem ID 184644
InChI Key AKWRNBWMGFUAMF-ZESMOPTKSA-N
Smiles [H]N[C@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ruff et al (2003) Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 1 51 PMID: 15043212

Rosi et al (2005) Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 134 671 PMID: 15979806

Polianova et al (2005) Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 67 83 PMID: 16002156


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Keywords: DAPTA, DAPTA supplier, Chemokine, receptor, 5, CCR5, antagonists, CXCR, Receptors, antiviral, Rantes, D-Ala-peptide, T-amide, Antivirals, CC, 2423, Tocris Bioscience

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