(D)-(+)-Neopterin

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Cat.No. 4656 - (D)-(+)-Neopterin | C9H11N5O4 | CAS No. 2009-64-5
Description: Stimulated by IFN-γ; marker of immune activation
Chemical Name: 2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Precursor of biopterin synthesis. Synthesized in response to interferon-γ stimulation; used as a marker of T helper cell-induced immune activation. Also an indicator of oxidative stress; modulates the effects of reactive oxygen species (ROS).

Technical Data

M. Wt 253.21
Formula C9H11N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2009-64-5
PubChem ID 448839
InChI Key BMQYVXCPAOLZOK-XINAWCOVSA-N
Smiles OC[C@@H](O)[C@@H](O)C2=NC1=C(N=C2)N=C(N)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.06 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 253.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.75 mL 39.49 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.39 mL 1.97 mL 3.95 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Murr et al (2002) Neopterin as a marker for immune system activation. Curr.Drug Metab. 3 175 PMID: 12003349

Huber et al (1984) Immune response-associated production of neopterin. J.Exp.Med. 160 310 PMID: 6429267


If you know of a relevant reference for (D)-(+)-Neopterin, please let us know.

View Related Products by Target

Keywords: cytokines IFN-gamma IFN-g IFN-γ immune markers oxidative stress indicators Cytokines

1 Citation for (D)-(+)-Neopterin

Citations are publications that use Tocris products. Selected citations for (D)-(+)-Neopterin include:

Kaminska et al (2016) Highly efficient SERS-based detection of cerebrospinal fluid neopterin as a diagnostic marker of bacterial infection. J Neurochem 408 4319 PMID: 27086021


Do you know of a great paper that uses (D)-(+)-Neopterin from Tocris? If so please let us know.

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Pathways for (D)-(+)-Neopterin

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