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Submit Review(D)-(+)-Neopterin
Description: Stimulated by IFN-γ; marker of immune activation
Chemical Name: 2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone
Purity: ≥98% (HPLC)
Biological Activity for (D)-(+)-Neopterin
(D)-(+)-Neopterin is a precursor of biopterin synthesis. Synthesized in response to interferon-γ stimulation; used as a marker of T helper cell-induced immune activation. Also an indicator of oxidative stress; modulates the effects of reactive oxygen species (ROS).
Compound Libraries for (D)-(+)-Neopterin
(D)-(+)-Neopterin is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for (D)-(+)-Neopterin
| M. Wt | 253.21 |
| Formula | C9H11N5O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2009-64-5 |
| PubChem ID | 448839 |
| InChI Key | BMQYVXCPAOLZOK-XINAWCOVSA-N |
| Smiles | OC[C@@H](O)[C@@H](O)C2=NC1=C(N=C2)N=C(N)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (D)-(+)-Neopterin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.06 | 20 with gentle warming |
Preparing Stock Solutions for (D)-(+)-Neopterin
The following data is based on the product molecular weight 253.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 19.75 mL | 98.73 mL | 197.46 mL |
| 1 mM | 3.95 mL | 19.75 mL | 39.49 mL |
| 2 mM | 1.97 mL | 9.87 mL | 19.75 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.95 mL |
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Product Datasheets for (D)-(+)-Neopterin
References for (D)-(+)-Neopterin
References are publications that support the biological activity of the product.
Murr et al (2002) Neopterin as a marker for immune system activation. Curr.Drug Metab. 3 175 PMID: 12003349
Huber et al (1984) Immune response-associated production of neopterin. J.Exp.Med. 160 310 PMID: 6429267
If you know of a relevant reference for (D)-(+)-Neopterin, please let us know.
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Keywords: (D)-(+)-Neopterin, (D)-(+)-Neopterin supplier, cytokines, IFN-gamma, IFN-g, IFN-γ, immune, markers, oxidative, stress, indicators, Cytokines, 4656, Tocris Bioscience
1 Citation for (D)-(+)-Neopterin
Citations are publications that use Tocris products. Selected citations for (D)-(+)-Neopterin include:
Kaminska et al (2016) Highly efficient SERS-based detection of cerebrospinal fluid neopterin as a diagnostic marker of bacterial infection. J Neurochem 408 4319 PMID: 27086021
Do you know of a great paper that uses (D)-(+)-Neopterin from Tocris? Please let us know.
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