Precursor of biopterin synthesis. Synthesized in response to interferon-γ stimulation; used as a marker of T helper cell-induced immune activation. Also an indicator of oxidative stress; modulates the effects of reactive oxygen species (ROS).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||5.06||20mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 253.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.95 mL||19.75 mL||39.49 mL|
|5 mM||0.79 mL||3.95 mL||7.9 mL|
|10 mM||0.39 mL||1.97 mL||3.95 mL|
|50 mM||0.08 mL||0.39 mL||0.79 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Murr et al (2002) Neopterin as a marker for immune system activation. Curr.Drug Metab. 3 175 PMID: 12003349
Huber et al (1984) Immune response-associated production of neopterin. J.Exp.Med. 160 310 PMID: 6429267
If you know of a relevant reference for (D)-(+)-Neopterin, please let us know.
Keywords: cytokines IFN-gamma IFN-g IFN-γ immune markers oxidative stress indicators Cytokines
1 Citation for (D)-(+)-Neopterin
Citations are publications that use Tocris products. Selected citations for (D)-(+)-Neopterin include:
Kaminska et al (2016) Highly efficient SERS-based detection of cerebrospinal fluid neopterin as a diagnostic marker of bacterial infection. J Neurochem 408 4319 PMID: 27086021
Do you know of a great paper that uses (D)-(+)-Neopterin from Tocris? If so please let us know.
Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.