D-erythro-Sphingosine (synthetic)

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Cat.No. 0633 - D-erythro-Sphingosine (synthetic) | C18H37NO2 | CAS No. 123-78-4
Description: Protein kinase C inhibitor
Chemical Name: trans-D-erythro-2-Amino-4-octadecene-1,3-diol

Biological Activity

Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.

Technical Data

M. Wt 299.5
Formula C18H37NO2
Storage Store at -20°C
CAS Number 123-78-4
PubChem ID 5280335

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mM in DMSO and to 50 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 299.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.69 mL 33.39 mL
5 mM 0.67 mL 3.34 mL 6.68 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Grossman (1990) Sphingosine inhibition and promotion of histamine release from isolated rat mast cells. Agents Actions 31 171 PMID: 1707581

Merrill et al (1989) Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry 28 3138 PMID: 2742830

If you know of a relevant reference for D-erythro-Sphingosine (synthetic), please let us know.

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Citations for D-erythro-Sphingosine (synthetic)

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