D-erythro-Sphingosine (synthetic)

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Cat.No. 0633 - D-erythro-Sphingosine (synthetic) | C18H37NO2 | CAS No. 123-78-4
Description: Protein kinase C inhibitor
Chemical Name: trans-D-erythro-2-Amino-4-octadecene-1,3-diol
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.

Technical Data

M. Wt 299.5
Formula C18H37NO2
Storage Store at -20°C
CAS Number 123-78-4
PubChem ID 5280335
InChI Key WWUZIQQURGPMPG-KRWOKUGFSA-N
Smiles N[C@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 5 mM in DMSO and to 50 mM in ethanol

References

References are publications that support the biological activity of the product.

Grossman (1990) Sphingosine inhibition and promotion of histamine release from isolated rat mast cells. Agents Actions 31 171 PMID: 1707581

Merrill et al (1989) Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry 28 3138 PMID: 2742830


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Keywords: D-erythro-Sphingosine (synthetic), D-erythro-Sphingosine (synthetic) supplier, Protein, kinase, C, inhibitors, inhibits, PKC, Kinases, Kinase, 0633, Tocris Bioscience

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