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Antagonist of phosphatidyl inositide-coupled mGlu receptors, less potent than the L-isomer (0273). Potent, and only known competitive inhibitor of phosphoserine phosphatase (more potent than L-isomer).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Hawkinson et al (1996) The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur.J.Pharmacol. 307 219 PMID: 8832224
Irving et al (1990) 1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons. Eur.J.Pharmacol. 186 363 PMID: 2289537
Schoepp et al (1990) Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid. Mol.Pharmacol. 38 222 PMID: 2166902
Keywords: D-AP3, D-AP3 supplier, Protein, Ser/Thr, Phosphatases, 0272, Tocris Bioscience
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