Discontinued ProductUnfortunately D-AP3 (Cat. No. 0272) has been withdrawn from sale for commercial reasons.
Antagonist of phosphatidyl inositide-coupled mGlu receptors, less potent than the L-isomer (0273). Potent, and only known competitive inhibitor of phosphoserine phosphatase (more potent than L-isomer).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 169.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.91 mL||29.57 mL||59.15 mL|
|5 mM||1.18 mL||5.91 mL||11.83 mL|
|10 mM||0.59 mL||2.96 mL||5.91 mL|
|50 mM||0.12 mL||0.59 mL||1.18 mL|
References are publications that support the products' biological activity.
Hawkinson et al (1996) The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur.J.Pharmacol. 307 219 PMID: 8832224
Irving et al (1990) 1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons. Eur.J.Pharmacol. 186 363 PMID: 2289537
Schoepp et al (1990) Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid. Mol.Pharmacol. 38 222 PMID: 2166902
Keywords: D-AP3, supplier, Protein, Ser/Thr, Phosphatases, Protein, Ser/Thr, Phosphatases, Tocris Bioscience
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