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CZC 24832

Cat. No. 4674 Submit a Review Datasheet / COA / SDS
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Cat.No. 4674 - CZC 24832 | C15H17FN6O2S | CAS No. 1159824-67-5
Description: Selective inhibitor of PI 3-kinase γ
Chemical Name: 5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide
Purity: ≥98% (HPLC)
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Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

CZC 24832 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 364.4
Formula C15H17FN6O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1159824-67-5
PubChem ID 42623951
InChI Key RXRZPHQBTHQXSV-UHFFFAOYSA-N
Smiles NC2=NN1C=C(C3=CN=CC(S(NC(C)(C)C)(=O)=O)=C3)C=C(F)C1=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bergamini et al (2012) A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat.Chem.Biol. 8 576 PMID: 22544264

If you know of a relevant reference for CZC 24832, please let us know.

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