CZC 24832

Discontinued Product

CZC 24832 (Cat. No. 4674) has been withdrawn from sale for commercial reasons.
Description: Selective inhibitor of PI 3-kinase γ
Chemical Name: 5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for CZC 24832

CZC 24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for CZC 24832

M. Wt 364.4
Formula C15H17FN6O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1159824-67-5
PubChem ID 42623951
Smiles NC2=NN1C=C(C3=CN=CC(S(NC(C)(C)C)(=O)=O)=C3)C=C(F)C1=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for CZC 24832

Certificate of Analysis / Product Datasheet
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References for CZC 24832

References are publications that support the biological activity of the product.

Bergamini et al (2012) A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat.Chem.Biol. 8 576 PMID: 22544264

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Keywords: CZC 24832, CZC 24832 supplier, CZC24832, PI3K, PI3-K, PI3kinase, phosphoinositide, 3-kinase, kinases, gamma, inhibitors, inhibits, inflammation, PI, 3-Kinase, Inositol, Lipids, 4674, Tocris Bioscience

Citations for CZC 24832

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Currently there are no citations for CZC 24832.

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