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Biological Activity for CZC 24832
CZC 24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data for CZC 24832
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for CZC 24832
References are publications that support the biological activity of the product.
Bergamini et al (2012) A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat.Chem.Biol. 8 576 PMID: 22544264
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Keywords: CZC 24832, CZC 24832 supplier, CZC24832, PI3K, PI3-K, PI3kinase, phosphoinositide, 3-kinase, kinases, gamma, inhibitors, inhibits, inflammation, PI, 3-Kinase, Inositol, Lipids, 4674, Tocris Bioscience
Citations for CZC 24832
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Currently there are no citations for CZC 24832.
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Literature in this Area
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