Cytosporone B

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Cat.No. 5459 - Cytosporone B | C18H26O5 | CAS No. 321661-62-5
Description: High affinity Nur77 agonist
Chemical Name: Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.

Technical Data

M. Wt 322.4
Formula C18H26O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 321661-62-5
PubChem ID 10687292
InChI Key UVVWQQKSNZLUQA-UHFFFAOYSA-N
Smiles OC1=CC(CC(OCC)=O)=C(C(CCCCCCC)=O)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 32.24 100
DMSO 32.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 322.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.02 mL
5 mM 0.62 mL 3.1 mL 6.2 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Palumbo-Zerr et al (2015) Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 21 150 PMID: 25581517

Zhan et al (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 4 548 PMID: 18690216


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Keywords: Cytosporone B, supplier, naturally, occurring, high, affinity, Nur77, NR4A1, agonists, agonism, TR3, NGFI-B, TIS1, NAK-1, apoptosis, blood, glucose, antifibrotic, fibrosis, Other, Nuclear, Receptors, Other, Transcription, Factors, Other, Nuclear, Receptors, Tocris Bioscience

Citations for Cytosporone B

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