Cytosporone B

Pricing Availability Delivery Time Qty
Cat.No. 5459 - Cytosporone B | C18H26O5 | CAS No. 321661-62-5
Description: High affinity Nur77 agonist
Chemical Name: Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
Purity: ≥98% (HPLC)

Biological Activity

Naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.

Technical Data

M. Wt 322.4
Formula C18H26O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 321661-62-5
PubChem ID 10687292

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 32.24 100
DMSO 32.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 322.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.02 mL
5 mM 0.62 mL 3.1 mL 6.2 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Palumbo-Zerr et al (2015) Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 21 150 PMID: 25581517

Zhan et al (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 4 548 PMID: 18690216

If you know of a relevant reference for Cytosporone B, please let us know.

View Related Products by Product Action

View all Other Nuclear Receptor Agonists

Keywords: Cytosporone B, supplier, naturally, occurring, high, affinity, Nur77, NR4A1, agonists, agonism, TR3, NGFI-B, TIS1, NAK-1, apoptosis, blood, glucose, antifibrotic, fibrosis, Other, Nuclear, Receptors, Other, Transcription, Factors, Other, Nuclear, Receptors, Tocris Bioscience

Citations for Cytosporone B

Citations are publications that use Tocris products.

Currently there are no citations for Cytosporone B. Do you know of a great paper that uses Cytosporone B from Tocris? If so please let us know.

Reviews for Cytosporone B

There are currently no reviews for this product. Be the first to review Cytosporone B and earn rewards!

Have you used Cytosporone B?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors