You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Cytosporone B
Cytosporone B is a naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.
Technical Data for Cytosporone B
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cytosporone B
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Cytosporone B
The following data is based on the product molecular weight 322.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.1 mL||15.51 mL||31.02 mL|
|5 mM||0.62 mL||3.1 mL||6.2 mL|
|10 mM||0.31 mL||1.55 mL||3.1 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References for Cytosporone B
References are publications that support the biological activity of the product.
Palumbo-Zerr et al (2015) Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 21 150 PMID: 25581517
Zhan et al (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 4 548 PMID: 18690216
If you know of a relevant reference for Cytosporone B, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Cytosporone B, Cytosporone B supplier, naturally, occurring, high, affinity, Nur77, NR4A1, agonists, agonism, TR3, NGFI-B, TIS1, NAK-1, apoptosis, blood, glucose, antifibrotic, fibrosis, Other, Transcription, Factors, Nerve, Growth, Factor, IB-like, Receptors, 5459, Tocris Bioscience
1 Citation for Cytosporone B
Citations are publications that use Tocris products. Selected citations for Cytosporone B include:
Mircea et al (2021) Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts. Am J Physiol Gastrointest Liver Physiol 321 G280-G297 PMID: 34288735
Do you know of a great paper that uses Cytosporone B from Tocris? Please let us know.
Reviews for Cytosporone B
There are currently no reviews for this product. Be the first to review Cytosporone B and earn rewards!
Have you used Cytosporone B?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.