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Submit ReviewCytosporone B
Description: High affinity Nur77 agonist
Chemical Name: Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
Purity: ≥98% (HPLC)
Biological Activity for Cytosporone B
Cytosporone B is a naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.
Technical Data for Cytosporone B
| M. Wt | 322.4 |
| Formula | C18H26O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 321661-62-5 |
| PubChem ID | 10687292 |
| InChI Key | UVVWQQKSNZLUQA-UHFFFAOYSA-N |
| Smiles | OC1=CC(CC(OCC)=O)=C(C(CCCCCCC)=O)C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cytosporone B
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.24 | 100 | |
| ethanol | 32.24 | 100 |
Preparing Stock Solutions for Cytosporone B
The following data is based on the product molecular weight 322.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.1 mL | 15.51 mL | 31.02 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.2 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.1 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets for Cytosporone B
References for Cytosporone B
References are publications that support the biological activity of the product.
Palumbo-Zerr et al (2015) Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 21 150 PMID: 25581517
Zhan et al (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 4 548 PMID: 18690216
If you know of a relevant reference for Cytosporone B, please let us know.
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1 Citation for Cytosporone B
Citations are publications that use Tocris products. Selected citations for Cytosporone B include:
Mircea et al (2021) Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts. Am J Physiol Gastrointest Liver Physiol 321 G280-G297 PMID: 34288735
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Literature in this Area
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for Cytosporone B
MAPK Signaling Pathway
The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.