Cyproheptadine hydrochloride

Discontinued Product

Cyproheptadine hydrochloride (Cat. No. 0996) has been withdrawn from sale for commercial reasons.
Cat.No. 0996 - Cyproheptadine hydrochloride | C21H21N.HCl | CAS No. 969-33-5
Description: 5-HT2 antagonist
Chemical Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidine)-methylpiperidine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity

Non-selective 5HT2 antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC50 = 1μM). Decreases expression and increases degradation of estrogen receptor (ER) α in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice.

Technical Data

M. Wt 323.86
Formula C21H21N.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 969-33-5
PubChem ID 13770
InChI Key ZPMVNZLARAEGHB-UHFFFAOYSA-N
Smiles Cl[H].CN1CC\C(CC1)=C1/C2=C(C=CC=C2)C=CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

View Related Products by Product Action

View all Non-selective 5-HT2 Antagonists

Keywords: Cyproheptadine hydrochloride, Cyproheptadine hydrochloride supplier, 5-HT2, antagonists, Non-Selective, Serotonin, Receptors, antagonism, inhibitors, inhibits, lysine, methyltransferase, SETD7/9, epigenetics, Non-selective, Other, Lysine, Methyltransferases, 0996, Tocris Bioscience

2 Citations for Cyproheptadine hydrochloride

Citations are publications that use Tocris products. Selected citations for Cyproheptadine hydrochloride include:

Fouad et al (2010) Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors. J Neurophysiol 104 2975 PMID: 20861436

Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126


Reviews for Cyproheptadine hydrochloride

There are currently no reviews for this product. Be the first to review Cyproheptadine hydrochloride and earn rewards!

Have you used Cyproheptadine hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.