Cyproheptadine hydrochloride

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Cat.No. 0996 - Cyproheptadine hydrochloride | C21H21N.HCl | CAS No. 969-33-5
Description: 5-HT2 antagonist
Chemical Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidine)-methylpiperidine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Non-selective 5HT2 antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC50 = 1μM). Decreases expression and increases degradation of estrogen receptor (ER) α in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice.

Technical Data

M. Wt 323.86
Formula C21H21N.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 969-33-5
PubChem ID 13770
InChI Key ZPMVNZLARAEGHB-UHFFFAOYSA-N
Smiles Cl[H].CN1CC\C(CC1)=C1/C2=C(C=CC=C2)C=CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 323.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.44 mL 30.88 mL
5 mM 0.62 mL 3.09 mL 6.18 mL
10 mM 0.31 mL 1.54 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Moran et al (1994) Inhibitory 5-hydroxytryptamine receptors involved in pressor effects obtained by stimulation of sympathetic outflow from spinal cord in pithed rats. Br.J.Pharmacol. 113 1358 PMID: 7889292

Takemoto et al (2016) Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription. J.Med.Chem. 59 3650 PMID: 27088648


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Keywords: Cyproheptadine hydrochloride, supplier, 5-HT2, antagonists, Non-Selective, Serotonin, Receptors, antagonism, inhibitors, inhibits, lysine, methyltransferase, SETD7/9, epigenetics, Non-selective, 5-HT2, Tocris Bioscience

2 Citations for Cyproheptadine hydrochloride

Citations are publications that use Tocris products. Selected citations for Cyproheptadine hydrochloride include:

Fouad et al (2010) Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors. J Neurophysiol 104 2975 PMID: 20861436

Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126


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GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for Cyproheptadine hydrochloride

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