Non-selective 5HT2 antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC50 = 1μM). Decreases expression and increases degradation of estrogen receptor (ER) α in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 323.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.09 mL||15.44 mL||30.88 mL|
|5 mM||0.62 mL||3.09 mL||6.18 mL|
|10 mM||0.31 mL||1.54 mL||3.09 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Moran et al (1994) Inhibitory 5-hydroxytryptamine receptors involved in pressor effects obtained by stimulation of sympathetic outflow from spinal cord in pithed rats. Br.J.Pharmacol. 113 1358 PMID: 7889292
Takemoto et al (2016) Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription. J.Med.Chem. 59 3650 PMID: 27088648
If you know of a relevant reference for Cyproheptadine hydrochloride, please let us know.
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Keywords: Cyproheptadine hydrochloride, supplier, 5-HT2, antagonists, Non-Selective, Serotonin, Receptors, antagonism, inhibitors, inhibits, lysine, methyltransferase, SETD7/9, epigenetics, Non-selective, 5-HT2, Tocris Bioscience
2 Citations for Cyproheptadine hydrochloride
Citations are publications that use Tocris products. Selected citations for Cyproheptadine hydrochloride include:
Fouad et al (2010) Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors. J Neurophysiol 104 2975 PMID: 20861436
Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126
Do you know of a great paper that uses Cyproheptadine hydrochloride from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.