CycLuc 1

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Cat.No. 6823 - CycLuc 1 | C13H11N3O2S2 | CAS No. 1247879-16-8
Description: Synthetic luciferase substrate; brain penetrant; displays NIR emission
Chemical Name: (4S)-2-(6,7-Dihydro-5H-pyrrolo[3,2-f]benzothiazol-2-yl)-4,5-dihydro-4-thiazolecarboxylic acid
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Synthetic luciferase substrate. Displays near-infrared (NIR) emission; peak luminescence at 599 nm. Suitable for use in in vivo bioluminescence imaging. Brain penetrant.

Technical Data

M. Wt 305.37
Formula C13H11N3O2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1247879-16-8
PubChem ID 91885395
Smiles OC([C@H]1CSC(C2=NC3=C(C=C4NCCC4=C3)S2)=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 305.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.37 mL 32.75 mL
5 mM 0.65 mL 3.27 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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References are publications that support the biological activity of the product.

Reddy et al (2010) Robust light emission from cyclic alkylaminoluciferin substrates for firefly luciferase. J.Am.Chem.Soc. 132 13586 PMID: 20828122

Evans et al (2014) A synthetic luciferin improves bioluminescence imaging in live mice. Nat.Methods. 11 393 PMID: 24509630

If you know of a relevant reference for CycLuc 1, please let us know.

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Literature in this Area

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