Home / Pharmacology / Enzymes / Kinases / Polo-like Kinase / Polo-like Kinase Inhibitors / Cyclapolin 9

Cyclapolin 9

Cat. No. 3116 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective, ATP-competitive PLK1 inhibitor
Chemical Name: 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Cyclapolin 9

Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC50 = 500 nM).

Technical Data for Cyclapolin 9

M. Wt 307.21
Formula C9H4F3N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 40533-25-3
PubChem ID 2779952
InChI Key FHFLXKUKCSDMLD-UHFFFAOYSA-N
Smiles [O-][N+]2=C(C(N)=O)SC1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cyclapolin 9

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.68 25
ethanol 3.07 10

Preparing Stock Solutions for Cyclapolin 9

The following data is based on the product molecular weight 307.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 13.02 mL 65.1 mL 130.2 mL
1.25 mM 2.6 mL 13.02 mL 26.04 mL
2.5 mM 1.3 mL 6.51 mL 13.02 mL
12.5 mM 0.26 mL 1.3 mL 2.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Cyclapolin 9

References are publications that support the biological activity of the product.

Taylor et al (2008) Ligand discovery and virtual screening using the program LIDAEUS. Br.J.Pharmacol. 153 S55 PMID: 18037921

McInnes et al (2006) Inhibitors of polo-like kinase reveal roles in spindle pole maintenance. Nature Chem.Biol. 2 608

If you know of a relevant reference for Cyclapolin 9, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Polo-like Kinase Inhibitors

Keywords: Cyclapolin 9, Cyclapolin 9 supplier, Selective, ATP-competitive, PLK1, inhibitors, inhibits, Polo-like, Kinase, Kinases, Cyclapolin9, Mitosis, 3116, Tocris Bioscience

1 Citation for Cyclapolin 9

Citations are publications that use Tocris products. Selected citations for Cyclapolin 9 include:

Cozzoli et al (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Proc Natl Acad Sci U S A 36 1623 PMID: 22432643

Do you know of a great paper that uses Cyclapolin 9 from Tocris? Please let us know.

Reviews for Cyclapolin 9

There are currently no reviews for this product. Be the first to review Cyclapolin 9 and earn rewards!

Have you used Cyclapolin 9?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.