Cyclapolin 9

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Cat.No. 3116 - Cyclapolin 9 | C9H4F3N3O4S | CAS No. 40533-25-3
Description: Selective, ATP-competitive PLK1 inhibitor
Chemical Name: 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC50 = 500 nM).

Technical Data

M. Wt 307.21
Formula C9H4F3N3O4S
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 40533-25-3
PubChem ID 2779952
InChI Key FHFLXKUKCSDMLD-UHFFFAOYSA-N
Smiles [O-][N+]2=C(C(N)=O)SC1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.68 25
ethanol 3.07 10

Preparing Stock Solutions

The following data is based on the product molecular weight 307.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.28 mL 32.55 mL
5 mM 0.65 mL 3.26 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Taylor et al (2008) Ligand discovery and virtual screening using the program LIDAEUS. Br.J.Pharmacol. 153 S55 PMID: 18037921

McInnes et al (2006) Inhibitors of polo-like kinase reveal roles in spindle pole maintenance. Nature Chem.Biol. 2 608


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Keywords: Cyclapolin 9, Cyclapolin 9 supplier, Selective, ATP-competitive, PLK1, inhibitors, inhibits, Polo-like, Kinase, Kinases, Cyclapolin9, Mitosis, 3116, Tocris Bioscience

1 Citation for Cyclapolin 9

Citations are publications that use Tocris products. Selected citations for Cyclapolin 9 include:

Cozzoli et al (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Proc Natl Acad Sci U S A 36 1623 PMID: 22432643


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Literature in this Area

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