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Selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC50 = 500 nM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 307.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||13.02 mL||65.1 mL||130.2 mL|
|1.25 mM||2.6 mL||13.02 mL||26.04 mL|
|2.5 mM||1.3 mL||6.51 mL||13.02 mL|
|12.5 mM||0.26 mL||1.3 mL||2.6 mL|
References are publications that support the biological activity of the product.
Taylor et al (2008) Ligand discovery and virtual screening using the program LIDAEUS. Br.J.Pharmacol. 153 S55 PMID: 18037921
McInnes et al (2006) Inhibitors of polo-like kinase reveal roles in spindle pole maintenance. Nature Chem.Biol. 2 608
If you know of a relevant reference for Cyclapolin 9, please let us know.
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Keywords: Cyclapolin 9, Cyclapolin 9 supplier, Selective, ATP-competitive, PLK1, inhibitors, inhibits, Polo-like, Kinase, Kinases, Cyclapolin9, Mitosis, 3116, Tocris Bioscience
1 Citation for Cyclapolin 9
Citations are publications that use Tocris products. Selected citations for Cyclapolin 9 include:
Cozzoli et al (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Proc Natl Acad Sci U S A 36 1623 PMID: 22432643
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Literature in this Area
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.