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Biological Activity for CU-T12-9
CU-T12-9 is a potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.
Sold under license from the University of Colorado
Compound Libraries for CU-T12-9
Technical Data for CU-T12-9
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CU-T12-9
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CU-T12-9
The following data is based on the product molecular weight 362.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.76 mL||13.8 mL||27.6 mL|
|5 mM||0.55 mL||2.76 mL||5.52 mL|
|10 mM||0.28 mL||1.38 mL||2.76 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
References for CU-T12-9
References are publications that support the biological activity of the product.
Cheng et al (2013) Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl. 51 12246 PMID: 22969053
Cheng et al (2015) Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv. 1 e1400139 PMID: 26101787
If you know of a relevant reference for CU-T12-9, please let us know.
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Keywords: CU-T12-9, CU-T12-9 supplier, Potent, TLR1/2, activators, activates, Toll-like, Receptors, 5414, Tocris Bioscience
Citations for CU-T12-9
Citations are publications that use Tocris products.
Currently there are no citations for CU-T12-9. Do you know of a great paper that uses CU-T12-9 from Tocris? Please let us know.
Reviews for CU-T12-9
Average Rating: 5 (Based on 1 Review.)
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