CU-T12-9

Pricing Availability Delivery Time Qty
Cat.No. 5414 - CU-T12-9 | C17H13F3N4O2
Description: Potent TLR1/2 agonist
Chemical Name: N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.

Licensing Information

Sold under license from the University of Colorado

Compound Libraries

CU-T12-9 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 362.31
Formula C17H13F3N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
PubChem ID 91826088
InChI Key LITXVDAFEYLWQE-UHFFFAOYSA-N
Smiles CNC1=CC=C([N+]([O-])=O)C=C1N2C=C(C3=CC=C(C(F)(F)F)C=C3)N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.23 100
ethanol 7.25 20

Preparing Stock Solutions

The following data is based on the product molecular weight 362.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.6 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cheng et al (2013) Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl. 51 12246 PMID: 22969053

Cheng et al (2015) Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv. 1 e1400139 PMID: 26101787


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Keywords: CU-T12-9, supplier, Potent, TLR1/2, activators, activates, Toll-like, Receptors, Toll-like, Receptors, Tocris Bioscience

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Pathways for CU-T12-9

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.