Discontinued Product

Cromakalim (Cat. No. 1377) has been withdrawn from sale for commercial reasons.
Cat.No. 1377 - Cromakalim | C16H18N2O3 | CAS No. 94470-67-4
Description: Kir6 (KATP) channel opener
Alternative Names: BRL 34915
Chemical Name: trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity: ≥99% (HPLC)
Citations (7)
Reviews (1)
Literature (3)

Biological Activity for Cromakalim

Cromakalim is a prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo.

Active Enantiomer also available.

Licensing Information

Sold under license

Technical Data for Cromakalim

M. Wt 286.33
Formula C16H18N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 94470-67-4
PubChem ID 76968376
Smiles O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3.O=C4CCCN4[C@@H]5[C@@H](O)C(C)(C)OC6=C5C=C(C#N)C=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Cromakalim

References are publications that support the biological activity of the product.

Escande et al (1988) The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes. Biochem.Biophys.Res.Commun. 154 620 PMID: 2456760

Longman et al (1988) Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil. J.Cardiovasc.Pharmacol. 12 535 PMID: 2468052

Wilson et al (1988) Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil. Eur.J.Pharmacol. 152 331 PMID: 2851450

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Keywords: Cromakalim, Cromakalim supplier, KATP, channel, openers, Potassium, KIR, Kir6, Channels, Inward, Rectifier, K+, BRL34915, BRL, 34915, rectifier, 1377, Tocris Bioscience

7 Citations for Cromakalim

Citations are publications that use Tocris products. Selected citations for Cromakalim include:

Seto et al (2013) Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes. Am J Physiol Heart Circ Physiol 8 e66404 PMID: 23799098

Institóris et al (2011) Impaired vascular responses of Ins-resistant rats after mild subarachnoid hemorrhage. PLoS One 300 H2080 PMID: 21421821

Mehmood et al (2015) Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation. PLoS One 15 75 PMID: 25886126

Mathias and Weid (2013) Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis. Am J Physiol Gastrointest Liver Physiol 304 G623 PMID: 23275612

Whidden et al (2016) Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats. J Exerc Nutrition Biochem 20 58 PMID: 27508155

Lasker et al (2013) The sGC activator BAY 60-2770 has potent erectile activity in the rat. Am J Physiol Heart Circ Physiol 304 H1670 PMID: 23585129

Erdos et al (2002) Alterations in KATP and KCa channel function in cerebral arteries of Ins-resistant rats. Am J Physiol Heart Circ Physiol 283 H2472 PMID: 12388242

Reviews for Cromakalim

Average Rating: 5 (Based on 1 Review.)

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Cromakalim used to study BK channel modulation.
By Sadequl Islam on 11/27/2018
Assay Type: In Vitro
Species: Human

Cromakalim was used to assess the channel opening properties when used on cell line that express BK channels. Gives consistent result that is reproducible.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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