Cromakalim

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Cat.No. 1377 - Cromakalim | C16H18N2O3 | CAS No. 94470-67-4
Description: Kir6 (KATP) channel opener
Alternative Names: BRL 34915
Chemical Name: trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

Prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo.

Active Enantiomer also available.

Licensing Information

Sold under license

Technical Data

M. Wt 286.33
Formula C16H18N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 94470-67-4
PubChem ID 76968376
InChI Key BVMDRSUIADWFLV-PNSAJKJISA-N
Smiles O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3.O=C4CCCN4[C@@H]5[C@@H](O)C(C)(C)OC6=C5C=C(C#N)C=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 20 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 286.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.92 mL
5 mM 0.7 mL 3.49 mL 6.98 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Escande et al (1988) The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes. Biochem.Biophys.Res.Commun. 154 620 PMID: 2456760

Longman et al (1988) Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil. J.Cardiovasc.Pharmacol. 12 535 PMID: 2468052

Wilson et al (1988) Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil. Eur.J.Pharmacol. 152 331 PMID: 2851450


If you know of a relevant reference for Cromakalim, please let us know.

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6 Citations for Cromakalim

Citations are publications that use Tocris products. Selected citations for Cromakalim include:

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Am J Physiol Heart Circ Physiol 8 e66404 PMID: 23799098

Institóris et al (2011) Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage. PLoS One 300 H2080 PMID: 21421821

Mehmood et al (2015) Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation. PLoS One 15 75 PMID: 25886126

Mathias and Weid (2013) Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis. Am J Physiol Gastrointest Liver Physiol 304 G623 PMID: 23275612

Erdos et al (2002) Alterations in KATP and KCa channel function in cerebral arteries of insulin-resistant rats. Am J Physiol Heart Circ Physiol 283 H2472 PMID: 12388242

Lasker et al (2013) The sGC activator BAY 60-2770 has potent erectile activity in the rat. Am J Physiol Heart Circ Physiol 304 H1670 PMID: 23585129


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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