Prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo.
Active Enantiomer also available.
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|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 20 mM in DMSO|
References are publications that support the biological activity of the product.
Escande et al (1988) The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes. Biochem.Biophys.Res.Commun. 154 620 PMID: 2456760
Longman et al (1988) Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil. J.Cardiovasc.Pharmacol. 12 535 PMID: 2468052
Wilson et al (1988) Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil. Eur.J.Pharmacol. 152 331 PMID: 2851450
If you know of a relevant reference for Cromakalim, please let us know.
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Keywords: Cromakalim, Cromakalim supplier, KATP, channel, openers, Potassium, KIR, Kir6, Channels, Inward, Rectifier, K+, BRL34915, BRL, 34915, rectifier, 1377, Tocris Bioscience
7 Citations for Cromakalim
Citations are publications that use Tocris products. Selected citations for Cromakalim include:
Erdos et al (2002) Alterations in KATP and KCa channel function in cerebral arteries of insulin-resistant rats. Am J Physiol Heart Circ Physiol 283 H2472 PMID: 12388242
Lasker et al (2013) The sGC activator BAY 60-2770 has potent erectile activity in the rat. Am J Physiol Heart Circ Physiol 304 H1670 PMID: 23585129
Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Am J Physiol Heart Circ Physiol 8 e66404 PMID: 23799098
Mehmood et al (2015) Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation. PLoS One 15 75 PMID: 25886126
Whidden et al (2016) Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats. J Exerc Nutrition Biochem 20 58 PMID: 27508155
Mathias and Weid (2013) Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis. Am J Physiol Gastrointest Liver Physiol 304 G623 PMID: 23275612
Institóris et al (2011) Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage. PLoS One 300 H2080 PMID: 21421821
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