CP 724714

Discontinued Product

CP 724714 (Cat. No. 5973) has been withdrawn from sale for commercial reasons.
Description: Potent and selective ErbB2 inhibitor
Chemical Name: 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for CP 724714

CP 724714 is a potent and selective ErbB2 inhibitor (IC50 = 10 nM). Exhibits 500-1000-fold selectivity for ErbB2 over ErbB1 and other related RTKs. Induces G1 cell cycle arrest in an ErbB2-overexpressing human cancer cell line. Promotes tumor apoptosis. Induces tumor regression in a human tumor xenograft model. Displays no apparent toxic effect on cardiac tissue.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information for CP 724714

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP-724714 is reviewed on the chemical probes website.

Technical Data for CP 724714

M. Wt 469.53
Formula C27H27N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 383432-38-0
PubChem ID 9874913
Smiles CC1=CC(NC2=NC=NC3=CC=C(/C=C/CNC(COC)=O)C=C32)=CC=C1OC4=CC=C(C)N=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CP 724714

References are publications that support the biological activity of the product.

Jani et al (2007) Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res. 67 9887 PMID: 17942920

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Citations for CP 724714

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Currently there are no citations for CP 724714.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

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