Potent and selective ErbB2 inhibitor (IC50 = 10 nM). Exhibits 500-1000-fold selectivity for ErbB2 over ErbB1 and other related RTKs. Induces G1 cell cycle arrest in an ErbB2-overexpressing human cancer cell line. Promotes tumor apoptosis. Induces tumor regression in a human tumor xenograft model. Displays no apparent toxic effect on cardiac tissue.
Sold for research purposes under agreement from Pfizer Inc.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP-724714 is reviewed on the chemical probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 469.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.13 mL||10.65 mL||21.3 mL|
|5 mM||0.43 mL||2.13 mL||4.26 mL|
|10 mM||0.21 mL||1.06 mL||2.13 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the biological activity of the product.
Jani et al (2007) Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res. 67 9887 PMID: 17942920
If you know of a relevant reference for CP 724714, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CP 724714, CP 724714 supplier, CP724714, HER2, ErbB2, inhibitors, inhibits, breast, cancer, tumour, tumor, apoptosis, potent, selective, EGFR, Apoptosis, Inducers, 5973, Tocris Bioscience
Citations for CP 724714
Citations are publications that use Tocris products.
Currently there are no citations for CP 724714. Do you know of a great paper that uses CP 724714 from Tocris? Please let us know.
Reviews for CP 724714
There are currently no reviews for this product. Be the first to review CP 724714 and earn rewards!
Have you used CP 724714?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.