CP 424174

Pricing Availability   Qty
Cat.No. 6107 - CP 424174 | C22H29ClN2O4S | CAS No. 210825-31-3
Description: Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
Chemical Name: N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for CP 424174

CP 424174 is an inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CP 424174

M. Wt 452.99
Formula C22H29ClN2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 210825-31-3
PubChem ID 9911728
Smiles O=S(C1=CC(C(O)(C)C)=CC=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 424174

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 45.3 100
DMSO 45.3 100

Preparing Stock Solutions for CP 424174

The following data is based on the product molecular weight 452.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.04 mL 22.08 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for CP 424174

References are publications that support the biological activity of the product.

Perregaux et al (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 299 187 PMID: 11561079

Baldwin et al (2016) Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 59 1691 PMID: 26422006

If you know of a relevant reference for CP 424174, please let us know.

Keywords: CP 424174, CP 424174 supplier, CP424174, Inhibitor, IL-1, beta, post-translational, processing, β, NLRP3, inflammasomes, in, vivo, orally, bioavailable, Cytokines, Inflammasomes, 6107, Tocris Bioscience

Citations for CP 424174

Citations are publications that use Tocris products.

Currently there are no citations for CP 424174. Do you know of a great paper that uses CP 424174 from Tocris? Please let us know.

Reviews for CP 424174

There are currently no reviews for this product. Be the first to review CP 424174 and earn rewards!

Have you used CP 424174?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.


Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Rheumatoid Arthritis

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.