CP 424174

Discontinued Product

CP 424174 (Cat. No. 6107) has been withdrawn from sale for commercial reasons.
Description: Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
Chemical Name: N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for CP 424174

CP 424174 is an inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CP 424174

M. Wt 452.99
Formula C22H29ClN2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 210825-31-3
PubChem ID 9911728
Smiles O=S(C1=CC(C(O)(C)C)=CC=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CP 424174

References are publications that support the biological activity of the product.

Perregaux et al (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 299 187 PMID: 11561079

Baldwin et al (2016) Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 59 1691 PMID: 26422006

Keywords: CP 424174, CP 424174 supplier, CP424174, Inhibitor, IL-1, beta, post-translational, processing, β, NLRP3, inflammasomes, in, vivo, orally, bioavailable, Cytokines, Inflammasomes, 6107, Tocris Bioscience

Citations for CP 424174

Citations are publications that use Tocris products.

Currently there are no citations for CP 424174.

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Literature in this Area

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Rheumatoid Arthritis Poster

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