CP 424174

Pricing Availability   Qty
Cat.No. 6107 - CP 424174 | C22H29ClN2O4S | CAS No. 210825-31-3
Description: Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
Chemical Name: N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 452.99
Formula C22H29ClN2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 210825-31-3
PubChem ID 9911728
InChI Key YRSBLSHMKVQWHP-UHFFFAOYSA-N
Smiles O=S(C1=CC(C(O)(C)C)=CC=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 45.3 100
DMSO 45.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 452.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.04 mL 22.08 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Perregaux et al (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 299 187 PMID: 11561079

Baldwin et al (2016) Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 59 1691 PMID: 26422006


If you know of a relevant reference for CP 424174, please let us know.

Keywords: CP 424174, CP 424174 supplier, CP424174, Inhibitor, IL-1, beta, post-translational, processing, β, NLRP3, inflammasomes, in, vivo, orally, bioavailable, Cytokines, Inflammasomes, 6107, Tocris Bioscience

Citations for CP 424174

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