Co 102862

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Cat.No. 2642 - Co 102862 | C14H12FN3O2 | CAS No. 181144-66-1
Description: State-dependent of voltage-gated sodium channels
Alternative Names: V102862
Chemical Name: 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Broad spectrum, state-dependent blocker of voltage-gated sodium channels. Displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Anticonvulsant; displays activity in rodent models of tonic/clonic and partial-complex seizures.

Technical Data

M. Wt 273.26
Formula C14H12FN3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 181144-66-1
PubChem ID 9816959
InChI Key MHUUDVZSPFRUSK-RQZCQDPDSA-N
Smiles NC(=O)N\N=C\C1=CC=C(OC2=CC=C(F)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 273.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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References

References are publications that support the biological activity of the product.

Ilyin et al (2005) V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Br.J.Pharmacol. 144 801 PMID: 15778702

Ilyin et al (2006) Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states. J.Pharmacol.Exp.Ther. 318 1083 PMID: 16728593


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Citations for Co 102862

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