Broad spectrum, state-dependent blocker of voltage-gated sodium channels. Displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Anticonvulsant; displays activity in rodent models of tonic/clonic and partial-complex seizures.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 273.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.66 mL||18.3 mL||36.6 mL|
|5 mM||0.73 mL||3.66 mL||7.32 mL|
|10 mM||0.37 mL||1.83 mL||3.66 mL|
|50 mM||0.07 mL||0.37 mL||0.73 mL|
References are publications that support the biological activity of the product.
Ilyin et al (2005) V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Br.J.Pharmacol. 144 801 PMID: 15778702
Ilyin et al (2006) Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states. J.Pharmacol.Exp.Ther. 318 1083 PMID: 16728593
If you know of a relevant reference for Co 102862, please let us know.
View Related Products by Product Action
Keywords: Co 102862, Co 102862 supplier, State-dependent, Na+, channel, blockers, anticonvulsant, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Co102862, V102862, Voltage-gated, 2642, Tocris Bioscience
Citations for Co 102862
Citations are publications that use Tocris products.
Currently there are no citations for Co 102862. Do you know of a great paper that uses Co 102862 from Tocris? Please let us know.
Reviews for Co 102862
There are currently no reviews for this product. Be the first to review Co 102862 and earn rewards!
Have you used Co 102862?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.