CM 10

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Description: ALDH1A inhibitor; depletes CD133+ cancer stem cells
Chemical Name: 2-(2-Propen-1-yl)-6-[[(1-propyl-1H-benzimidazol-2-yl)amino]methyl]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity for CM 10

CM 10 is a aldehyde dehydrogenase 1A (ALDH1A) inhibitor (IC50 values are 0.64, 0.74 and 1.7 μM for ALDH1A3, ALDH1A2 and ALDH1A1, respectively). Induces a necroptotic phenotype and preferentially depletes CD133+ ovarian cancer stem cells in vitro.

Technical Data for CM 10

M. Wt 321.42
Formula C20H23N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 692269-09-3
PubChem ID 889692
InChI Key ZFHWEWJDCFGRBO-UHFFFAOYSA-N
Smiles CCCN1C(NCC2=C(O)C(CC=C)=CC=C2)=NC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CM 10

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.14 100

Preparing Stock Solutions for CM 10

The following data is based on the product molecular weight 321.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.11 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References for CM 10

References are publications that support the biological activity of the product.

Chefetz et al (2019) A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 26 3061 PMID: 30865894

Morgan & Hurley (2015) Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chem.Biol.Interact. 234 29 PMID: 25450233


If you know of a relevant reference for CM 10, please let us know.

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Keywords: CM 10, CM 10 supplier, CM10, aldehyde, dehydrogenase, inhibitors, inhibits, ALDH1A, cancer, stem, cells, Aldehyde, Dehydrogenase, Cancer, Stem, Cells, 6933, Tocris Bioscience

Citations for CM 10

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