CM 10

Pricing Availability   Qty
Cat.No. 6933 - CM 10 | C20H23N3O | CAS No. 692269-09-3
Description: ALDH1A inhibitor; depletes CD133+ cancer stem cells
Chemical Name: 2-(2-Propen-1-yl)-6-[[(1-propyl-1H-benzimidazol-2-yl)amino]methyl]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for CM 10

CM 10 is a aldehyde dehydrogenase 1A (ALDH1A) inhibitor (IC50 values are 0.64, 0.74 and 1.7 μM for ALDH1A3, ALDH1A2 and ALDH1A1, respectively). Induces a necroptotic phenotype and preferentially depletes CD133+ ovarian cancer stem cells in vitro.

Technical Data for CM 10

M. Wt 321.42
Formula C20H23N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 692269-09-3
PubChem ID 889692
InChI Key ZFHWEWJDCFGRBO-UHFFFAOYSA-N
Smiles CCCN1C(NCC2=C(O)C(CC=C)=CC=C2)=NC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CM 10

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.14 100

Preparing Stock Solutions for CM 10

The following data is based on the product molecular weight 321.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.11 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for CM 10

References are publications that support the biological activity of the product.

Chefetz et al (2019) A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 26 3061 PMID: 30865894

Morgan & Hurley (2015) Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chem.Biol.Interact. 234 29 PMID: 25450233


If you know of a relevant reference for CM 10, please let us know.

View Related Products by Product Action

View all Aldehyde Dehydrogenase Inhibitors

Keywords: CM 10, CM 10 supplier, CM10, aldehyde, dehydrogenase, inhibitors, inhibits, ALDH1A, cancer, stem, cells, Aldehyde, Dehydrogenase, Cancer, Stem, Cells, 6933, Tocris Bioscience

Citations for CM 10

Citations are publications that use Tocris products.

Currently there are no citations for CM 10. Do you know of a great paper that uses CM 10 from Tocris? Please let us know.

Reviews for CM 10

There are currently no reviews for this product. Be the first to review CM 10 and earn rewards!

Have you used CM 10?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review