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Description: Deoxyadenosine analog; pro-apoptotic
Alternative Names: 2-Chloro-2'-deoxyadenosine
Chemical Name: (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)
Pathways (1)

Biological Activity for Cladribine

Cladribine is an adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28 μM). Displays activity in vitro and in vivo. Orally bioavailable.

Technical Data for Cladribine

M. Wt 285.69
Formula C10H12ClN5O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 4291-63-8
PubChem ID 20279
Smiles OC[C@H]1O[C@@H](N2C=NC3=C2N=C(Cl)N=C3N)C[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cladribine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.57 100

Preparing Stock Solutions for Cladribine

The following data is based on the product molecular weight 285.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.5 mL 35 mL
5 mM 0.7 mL 3.5 mL 7 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References for Cladribine

References are publications that support the biological activity of the product.

Bryson et al (1993) Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies. Drugs 46 872 PMID: 7507037

Robak et al (2006) Older and new formulations of cladr. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat. Anticancer Drug Discov. 1 23 PMID: 18221024

Seto et al (1985) Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 75 377 PMID: 2579098

If you know of a relevant reference for Cladribine, please let us know.

Keywords: Cladribine, Cladribine supplier, leukemia, adenosine, deaminase, antileukemic, proapoptotic, ribonuclease, reductase, deoxyadenosine, analogue, analog, 2-Chloro-2-deoxyadenosine, antimetabolites, 2-Chloro-2'-deoxyadenosine, Apoptosis, Inducers, Ribonucleotide, Reductase, 5292, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Cladribine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to

1 Citation for Cladribine

Citations are publications that use Tocris products. Selected citations for Cladribine include:

Weiterer et al (2015) Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium. J Biomed Sci 10 e0143163 PMID: 26571499

Do you know of a great paper that uses Cladribine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Cladribine

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.