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Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers.
Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. There are three classes of RNRs (Classes I - III), but only class I are present in eukaryotes. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers and a unique feature of note is the requirement of a free radical for catalytic activity.
RNRs are allosterically regulated by the relative concentrations of ATP:dATP. In addition, to ensure a balanced supply of nucleotides for DNA synthesis, RNR substrate specificity is modulated by ATP and GTP binding to the active site. Perturbations in RNR expression is a hallmark of malignant transformation and many cancer therapies target this enzyme.
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