Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers.
Ribonucleotide Reductase Inhibitors |
|
---|---|
Cat. No. | Product Name / Activity |
5962 | 3-AP |
Ribonucleotide reductase inhibitor; also an iron chelator | |
5292 | Cladribine |
Ribonuclease reductase inhibitor; deoxyadenosine analog | |
3259 | Gemcitabine hydrochloride |
Ribonucleotide reductase inhibitor |
Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. There are three classes of RNRs (Classes I - III), but only class I are present in eukaryotes. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers and a unique feature of note is the requirement of a free radical for catalytic activity.
RNRs are allosterically regulated by the relative concentrations of ATP:dATP. In addition, to ensure a balanced supply of nucleotides for DNA synthesis, RNR substrate specificity is modulated by ATP and GTP binding to the active site. Perturbations in RNR expression is a hallmark of malignant transformation and many cancer therapies target this enzyme.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
RRM1 | Human | RRM1 | NM_001033 | P23921 |
Mouse | Rrm1 | NM_009103 | P07742 | |
Rat | Rrm1 | NM_001013236 | Q5U2Q5 | |
RRM2 | Human | RRM2 | NM_001034 | Q96GD4 |
Mouse | Rrm2 | NM_009104 | P11157 | |
Rat | Rrm2 | NM_001025740 | Q4KLN6 | |
RRM2B | Human | RRM2B | NM_015713 | Q9NTD8 |
Mouse | Rrm2b | NM_199476 | Q6PEE3 | |
Rat | Rrm2b | NM_001130543 | XP_235367 |