Ribonucleotide Reductase

Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5962 3-AP
Ribonucleotide reductase inhibitor; also an iron chelator
5292 Cladribine
Ribonuclease reductase inhibitor; deoxyadenosine analog
3259 Gemcitabine hydrochloride
Ribonucleotide reductase inhibitor

Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. There are three classes of RNRs (Classes I - III), but only class I are present in eukaryotes. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers and a unique feature of note is the requirement of a free radical for catalytic activity.

RNRs are allosterically regulated by the relative concentrations of ATP:dATP. In addition, to ensure a balanced supply of nucleotides for DNA synthesis, RNR substrate specificity is modulated by ATP and GTP binding to the active site. Perturbations in RNR expression is a hallmark of malignant transformation and many cancer therapies target this enzyme.

Literature for Ribonucleotide Reductase

Tocris offers the following scientific literature for Ribonucleotide Reductase to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Ribonucleotide Reductase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
RRM1 Human RRM1 NM_001033 P23921
Mouse Rrm1 NM_009103 P07742
Rat Rrm1 NM_001013236 Q5U2Q5
RRM2 Human RRM2 NM_001034 Q96GD4
Mouse Rrm2 NM_009104 P11157
Rat Rrm2 NM_001025740 Q4KLN6
RRM2B Human RRM2B NM_015713 Q9NTD8
Mouse Rrm2b NM_199476 Q6PEE3
Rat Rrm2b NM_001130543 XP_235367