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Ribonucleotide Reductase

Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers.

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Background
Gene Data

Ribonucleotide Reductase Inhibitors
Cat. No. Product Name / Activity
5962 3-AP
Ribonucleotide reductase inhibitor; also an iron chelator
5292 Cladribine
Ribonuclease reductase inhibitor; deoxyadenosine analog
3259 Gemcitabine hydrochloride
Ribonucleotide reductase inhibitor

Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. There are three classes of RNRs (Classes I - III), but only class I are present in eukaryotes. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers and a unique feature of note is the requirement of a free radical for catalytic activity.

RNRs are allosterically regulated by the relative concentrations of ATP:dATP. In addition, to ensure a balanced supply of nucleotides for DNA synthesis, RNR substrate specificity is modulated by ATP and GTP binding to the active site. Perturbations in RNR expression is a hallmark of malignant transformation and many cancer therapies target this enzyme.

External sources of pharmacological information for Ribonucleotide Reductase :

    Ribonucleotide Reductase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    RRM1 Human RRM1 NM_001033 P23921
    Mouse Rrm1 NM_009103 P07742
    Rat Rrm1 NM_001013236 Q5U2Q5
    RRM2 Human RRM2 NM_001034 Q96GD4
    Mouse Rrm2 NM_009104 P11157
    Rat Rrm2 NM_001025740 Q4KLN6
    RRM2B Human RRM2B NM_015713 Q9NTD8
    Mouse Rrm2b NM_199476 Q6PEE3
    Rat Rrm2b NM_001130543 XP_235367