Cinnabarinic acid

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Cat.No. 4119 - Cinnabarinic acid | C14H8N2O6 | CAS No. 606-59-7
Description: Selective mGlu4 agonist
Chemical Name: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

mGlu4 receptor agonist. Activates mGlu4 receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1, mGlu2 and mGlu5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.

Technical Data

M. Wt 300.22
Formula C14H8N2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 606-59-7
PubChem ID 114918
InChI Key FSBKJYLVDRVPTK-UHFFFAOYSA-N
Smiles O=C2C(N)=C(C(O)=O)C1=NC3=C(C=CC=C3C(O)=O)OC1=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 300.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.31 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.67 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Fazio (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors. Mol.Pharmacol. Feb 6 Epub ahead of print PMID: 22311707


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Citations for Cinnabarinic acid

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