Cilostazol

Pricing Availability Delivery Time Qty
Cat.No. 1692 - Cilostazol | C20H27N5O2 | CAS No. 73963-72-1
Description: PDE3A inhibitor. Also adenosine uptake inhibitor
Chemical Name: 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent phosphodiesterase III A (PDE3A) inhibitor (IC50 = 0.2 μM) and inhibitor of adenosine uptake. Has antimitogenic, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.

Compound Libraries

Cilostazol is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 369.47
Formula C20H27N5O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 73963-72-1
PubChem ID 2754
InChI Key RRGUKTPIGVIEKM-UHFFFAOYSA-N
Smiles O=C1CCC2=CC(OCCCCC3=NN=NN3C3CCCCC3)=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.47 50
ethanol 3.69 10

Preparing Stock Solutions

The following data is based on the product molecular weight 369.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.53 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Schror (2002) The pharmacology of cilostazol. Diabetes Obes.Metab. 4 S14 PMID: 12180353

Shintani et al (1985) General pharmacological properties of cilostazol, a new antithrombotic drug. Part I: effects on the central nervous system. Arzneimittelforschung 35 1157 PMID: 4074429

Shintani et al (1985) General pharmacological properties of cilostazol, a new antithrombotic drug. Part II: effects on the peripheral organs. Arzneimittelforschung 35 1163 PMID: 3000392


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Keywords: Cilostazol, supplier, PDE3A, inhibitors, inhibits, adenosines, reuptake, Phosphodiesterases, ENT1, Purine, Transporters, Pyrimidine, Equilibrative, Nucleoside, Monoamine, Neurotransmitter, Phosphodiesterases, Nucleoside, Transporters, Phosphodiesterases, Tocris Bioscience

Citations for Cilostazol

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