Cilastatin sodium

Pricing Availability Delivery Time Qty
Cat.No. 2709 - Cilastatin sodium | C16H25N2NaO5S | CAS No. 81129-83-1
Description: Dipeptidase inhibitor
Alternative Names: MK 0791
Chemical Name: (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Dipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a Ki value of 0.11 μM. Inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.

Technical Data

M. Wt 380.43
Formula C16H25N2NaO5S
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 81129-83-1
PubChem ID 23702512
InChI Key QXPBTTUOVWMPJN-VQAYNFQASA-M
Smiles [Na+].N[C@H](CSCCCC\C=C(/NC(=O)[C@H]1CC1(C)C)C(O)=O)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.8 10
water 38.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 380.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.14 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Graham et al (1987) Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. J.Med.Chem. 30 1074 PMID: 3495664

White et al (1999) A continuous fluorometric assay for leukotriene D4 hydrolase. Anal.Biochem. 268 245 PMID: 10075814

Perez et al (2004) Inhibition of brush border dipeptidase with cilastatin reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. Nephrol.Dial.Transplant. 19 2445 PMID: 15252165


If you know of a relevant reference for Cilastatin sodium, please let us know.

View Related Products by Product Action

View all Other Protease Inhibitors

Keywords: Dipeptidase LTDase leukotrienes eicosanoids D4 hydrolase dehydropeptidase I inhibitors inhibits metabolism LTD4 LTE4 Proteases Proteinases MK0791 MK 0791 Other Proteases

Citations for Cilastatin sodium

Citations are publications that use Tocris products.

Currently there are no citations for Cilastatin sodium. Do you know of a great paper that uses Cilastatin sodium from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Cilastatin sodium

Protocols

TODO: Add Protocols