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Dipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a Ki value of 0.11 μM. Inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 380.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.63 mL||13.14 mL||26.29 mL|
|5 mM||0.53 mL||2.63 mL||5.26 mL|
|10 mM||0.26 mL||1.31 mL||2.63 mL|
|50 mM||0.05 mL||0.26 mL||0.53 mL|
References are publications that support the biological activity of the product.
Graham et al (1987) Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. J.Med.Chem. 30 1074 PMID: 3495664
White et al (1999) A continuous fluorometric assay for leukotriene D4 hydrolase. Anal.Biochem. 268 245 PMID: 10075814
Perez et al (2004) Inhibition of brush border dipeptidase with cilas. reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. Nephrol.Dial.Transplant. 19 2445 PMID: 15252165
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Keywords: Cilastatin sodium, Cilastatin sodium supplier, Dipeptidase, LTDase, leukotrienes, eicosanoids, D4, hydrolase, dehydropeptidase, I, inhibitors, inhibits, metabolism, LTD4, LTE4, Proteases, Proteinases, MK0791, MK, 0791, Other, Leukotriene, and, Related, Receptors, 2709, Tocris Bioscience
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Literature in this Area
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