CID 755673

Pricing Availability Delivery Time Qty
Cat.No. 3327 - CID 755673 | C12H11NO3 | CAS No. 521937-07-5
Description: Selective protein kinase D inhibitor
Chemical Name: 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Literature

Biological Activity

Selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.

Technical Data

M. Wt 217.22
Formula C12H11NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 521937-07-5
PubChem ID 755673
InChI Key AACFPJSJOWQNBN-UHFFFAOYSA-N
Smiles OC1=CC2=C(OC3=C2CCCNC3=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.72 100
ethanol 1.09 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 217.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.6 mL 23.02 mL 46.04 mL
5 mM 0.92 mL 4.6 mL 9.21 mL
10 mM 0.46 mL 2.3 mL 4.6 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sharlow et al (2008) Potent and selective disruption of protein kinase D functionality by benzoxoloazepinolone. J.Biol.Chem. 283 33516 PMID: 18829454


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Keywords: CID 755673, supplier, Selective, protein, kinases, D, inhibitors, inhibits, PKD, CID755673, Protein, Kinase, D, Protein, Kinase, D, Tocris Bioscience

8 Citations for CID 755673

Citations are publications that use Tocris products. Selected citations for CID 755673 include:

Rezaee et al (2013) Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption. J Virol 87 11088 PMID: 23926335

Kienzle et al (2013) PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Mol Biol Cell 24 222 PMID: 23242995

Subathra et al (2011) Sphingomyelin synthases regulate protein trafficking and secretion. PLoS One 6 e23644 PMID: 21980337

Qureshi et al (2011) Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans. PLoS One 5 e15587 PMID: 21203393

Bhattacharya et al (2011) Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor. Blood 118 4179 PMID: 21821707

Spratley et al (2011) Protein kinase D regulates cofilin activity through p21-activated kinase 4. Sci Signal 286 34254 PMID: 21832093

Torres-Marquez et al (2010) CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway. J Biol Chem 391 63 PMID: 19896460

Xu et al (2015) GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis. Biochem Biophys Res Commun 26 874 PMID: 25568344


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