CID 755673

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Cat.No. 3327 - CID 755673 | C12H11NO3 | CAS No. 521937-07-5
Description: Selective protein kinase D inhibitor
Chemical Name: 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations (12)
Reviews (1)
Literature (2)

Biological Activity

Selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.

Compound Libraries

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Technical Data

M. Wt 217.22
Formula C12H11NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 521937-07-5
PubChem ID 755673
InChI Key AACFPJSJOWQNBN-UHFFFAOYSA-N
Smiles OC1=CC2=C(OC3=C2CCCNC3=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.72 100

Preparing Stock Solutions

The following data is based on the product molecular weight 217.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.6 mL 23.02 mL 46.04 mL
5 mM 0.92 mL 4.6 mL 9.21 mL
10 mM 0.46 mL 2.3 mL 4.6 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Sharlow et al (2008) Potent and selective disruption of protein kinase D functionality by benzoxoloazepinolone. J.Biol.Chem. 283 33516 PMID: 18829454


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Keywords: CID 755673, CID 755673 supplier, Selective, protein, kinases, D, inhibitors, inhibits, PKD, CID755673, Protein, Kinase, 3327, Tocris Bioscience

12 Citations for CID 755673

Citations are publications that use Tocris products. Selected citations for CID 755673 include:

Chen and Kan (2015) Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells. Biochim Biophys Acta 1853 2662 PMID: 26241492

Rezaee et al (2013) Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption. J Virol 87 11088 PMID: 23926335

Kienzle et al (2013) PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Mol Biol Cell 24 222 PMID: 23242995

Zhang et al (2017) Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med 214 2671 PMID: 28716882


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Reviews for CID 755673

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Effect of CID 755673 on PKD has been under observation..
By Anonymous on 01/16/2020
Species: Human

Effect of CID 755673 on PKD has been under observation. Changes in the FRET ratio from COS-7 cells expressing the kinase activity reporter, DKAR, following activation of endogenous PKD (light blue diamonds) or overexpressed PKD (dark blue diamonds) via 200 nM PDBu treatment and subsequent PKD inhibition with the non-competitive CID 755673 (50 μM).

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