You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
CI 898 trihydrochloride
Discontinued ProductCI 898 trihydrochloride (Cat. No. 2039) has been withdrawn from sale for commercial reasons.
Potent lipophilic inhibitor of dihydrofolate reductase (DHFR) that displays antineoplastic and antiprotozoal properties. Inhibits protozoal, bacterial and human DHFR with IC50 values of 1.4, 6.1 and 3.2 nM respectively. Affects G1/S phase cell cycle progression.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Hook et al (1986) Cell cycle effects of trimetrexate (CI-898). Cancer Chemother.Pharmacol. 16 116 PMID: 2936525
Chan and Anderson (2006) Towards species-specific antifolates. Curr.Med.Chem. 13 377 PMID: 16475929
Allegra et al (1987) Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate. J.Clin.Invest. 79 478 PMID: 2948969
View Related Products by Product Action
Keywords: CI 898 trihydrochloride, CI 898 trihydrochloride supplier, Dihydrofolate, reductases, inhibitors, inhibits, Antineoplastic, agent, affects, G1/S, phase, progression, DHFR, Cell, Cycle, CI898, trihydrochloride, TMTX, Trimetrexate, Reductase, Inhibitors, 2039, Tocris Bioscience
1 Citation for CI 898 trihydrochloride
Citations are publications that use Tocris products. Selected citations for CI 898 trihydrochloride include:
Sienkiewicz et al (2008) Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes. Mol Microbiol 69 520 PMID: 18557814
Reviews for CI 898 trihydrochloride
There are currently no reviews for this product. Be the first to review CI 898 trihydrochloride and earn rewards!
Have you used CI 898 trihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]New
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells