CHR 2797

Pricing Availability Delivery Time Qty
Cat.No. 3595 - CHR 2797 | C21H30N2O6 | CAS No. 238750-77-1
Description: Aminopeptidase inhibitor
Alternative Names: Tosedostat
Chemical Name: α-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-benzeneacetic acid cyclopently ester
Purity: ≥98% (HPLC)

Biological Activity

Aminopeptidase inhibitor (IC50 values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2 respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo.

Technical Data

M. Wt 406.48
Formula C21H30N2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 238750-77-1
PubChem ID 15547703
Smiles O=C([C@H]([C@]2=CC=CC=C2)NC([C@@H]([C@@H](C(NO)=O)O)CC(C)C)=O)OC1CCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.65 100
ethanol 20.32 50

Preparing Stock Solutions

The following data is based on the product molecular weight 406.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Krige et al (2008) CHR-2797: an anitproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 68 6669 PMID: 18701491

Moore et al (2009) Aminopeptidase inhibition as a targeted treatment strategy in myeloma. Mol.Cancer Ther. 8 762 PMID: 19372548

If you know of a relevant reference for CHR 2797, please let us know.

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Keywords: CHR 2797, supplier, aminopeptidases, inhibitors, inhibits, proteases, proteinases, CHR2797, Tosedostat, Aminopeptidases, Aminopeptidases, Tocris Bioscience

Citations for CHR 2797

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Pathways for CHR 2797


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