CHR 2797

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Cat.No. 3595 - CHR 2797 | C21H30N2O6 | CAS No. 238750-77-1
Description: Aminopeptidase inhibitor
Alternative Names: Tosedostat
Chemical Name: α-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-benzeneacetic acid cyclopently ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Aminopeptidase inhibitor (IC50 values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2 respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo.

Technical Data

M. Wt 406.48
Formula C21H30N2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 238750-77-1
PubChem ID 15547703
InChI Key FWFGIHPGRQZWIW-SQNIBIBYSA-N
Smiles O=C([C@H]([C@]2=CC=CC=C2)NC([C@@H]([C@@H](C(NO)=O)O)CC(C)C)=O)OC1CCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.65 100
ethanol 20.32 50

Preparing Stock Solutions

The following data is based on the product molecular weight 406.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Krige et al (2008) CHR-2797: an anitproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 68 6669 PMID: 18701491

Moore et al (2009) Aminopeptidase inhibition as a targeted treatment strategy in myeloma. Mol.Cancer Ther. 8 762 PMID: 19372548


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Keywords: CHR 2797, CHR 2797 supplier, aminopeptidases, inhibitors, inhibits, proteases, proteinases, CHR2797, Tosedostat, Aminopeptidases, 3595, Tocris Bioscience

Citations for CHR 2797

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Literature in this Area

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