You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Aminopeptidase inhibitor (IC50 values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo. Also inhibits neprilysin (IC50 = 900 nM). Exhibits antinociceptive activity and enhances the efficacy of Morphine (Cat. No. 5158) in the hot-plate and tail-flick assays, via an action on the peripheral nervous system.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 406.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.46 mL||12.3 mL||24.6 mL|
|5 mM||0.49 mL||2.46 mL||4.92 mL|
|10 mM||0.25 mL||1.23 mL||2.46 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
References are publications that support the biological activity of the product.
Krige et al (2008) CHR-2797: an anitproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 68 6669 PMID: 18701491
Moore et al (2009) Aminopeptidase inhibition as a targeted treatment strategy in myeloma. Mol.Cancer Ther. 8 762 PMID: 19372548
Singh et al (2019) Discovery of anticancer clinical candidate, Tosedostat, as an analgesic agent. ACS Chem.Neurosci. 10 4007 PMID: 31415151
If you know of a relevant reference for CHR 2797, please let us know.
View Related Products by Product Action
Keywords: CHR 2797, CHR 2797 supplier, aminopeptidases, inhibitors, inhibits, proteases, proteinases, CHR2797, neprilysin, neutral, endopeptidase, NEP, Tosedostat, Aminopeptidases, 3595, Tocris Bioscience
Citations for CHR 2797
Citations are publications that use Tocris products.
Currently there are no citations for CHR 2797. Do you know of a great paper that uses CHR 2797 from Tocris? Please let us know.
Reviews for CHR 2797
There are currently no reviews for this product. Be the first to review CHR 2797 and earn rewards!
Have you used CHR 2797?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]New
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells