CHPG Sodium salt

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Description: Selective mGlu5 agonist; sodium salt of CHPG (Cat. No. 1049)
Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine sodium salt
Purity: ≥99% (HPLC)
Citations (2)
Literature (5)

Biological Activity for CHPG Sodium salt

CHPG Sodium salt is a sodium salt of the selective mGlu5 agonist CHPG (Cat. No. 1049).

Compound Libraries for CHPG Sodium salt

CHPG Sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CHPG Sodium salt

M. Wt 223.59
Formula C8H7ClNNaO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1303993-73-8
PubChem ID 52974246
Smiles [Na+].NC(C([O-])=O)C1=CC(O)=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CHPG Sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 11.18 50
DMSO 11.18 50

Preparing Stock Solutions for CHPG Sodium salt

The following data is based on the product molecular weight 223.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.94 mL 44.72 mL 89.45 mL
2.5 mM 1.79 mL 8.94 mL 17.89 mL
5 mM 0.89 mL 4.47 mL 8.94 mL
25 mM 0.18 mL 0.89 mL 1.79 mL

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Product Datasheets for CHPG Sodium salt

Certificate of Analysis / Product Datasheet
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References for CHPG Sodium salt

References are publications that support the biological activity of the product.

Doherty et al (1997) (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36 265 PMID: 9144665

Salt et al (1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 127 1057 PMID: 10455248

Bao et al (2001) Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 922 173 PMID: 11743947

If you know of a relevant reference for CHPG Sodium salt, please let us know.

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2 Citations for CHPG Sodium salt

Citations are publications that use Tocris products. Selected citations for CHPG Sodium salt include:

Hyuk Soo et al (2021) Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells. Hepatology 74 2170-2185 PMID: 33932306

Yangyang et al (2021) CHPG enhances BDNF and myelination in cuprizone-treated mice through astrocytic metabotropic glutamate receptor 5. Glia 69 1950-1965 PMID: 33811383

Do you know of a great paper that uses CHPG Sodium salt from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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