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CHPG Sodium salt
Biological Activity for CHPG Sodium salt
CHPG Sodium salt is a sodium salt of the selective mGlu5 agonist CHPG (Cat. No. 1049).
Compound Libraries for CHPG Sodium salt
Technical Data for CHPG Sodium salt
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CHPG Sodium salt
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CHPG Sodium salt
The following data is based on the product molecular weight 223.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.94 mL||44.72 mL||89.45 mL|
|2.5 mM||1.79 mL||8.94 mL||17.89 mL|
|5 mM||0.89 mL||4.47 mL||8.94 mL|
|25 mM||0.18 mL||0.89 mL||1.79 mL|
Product Datasheets for CHPG Sodium salt
References for CHPG Sodium salt
References are publications that support the biological activity of the product.
Doherty et al (1997) (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36 265 PMID: 9144665
Salt et al (1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 127 1057 PMID: 10455248
Bao et al (2001) Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 922 173 PMID: 11743947
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Keywords: CHPG Sodium salt, CHPG Sodium salt supplier, mGlu5, mGluR5, selective, agonist, mGlur, Group, I, Receptors, Glutamate, Metabotropic, (Metabotropic), 3695, Tocris Bioscience
2 Citations for CHPG Sodium salt
Citations are publications that use Tocris products. Selected citations for CHPG Sodium salt include:
Hyuk Soo et al (2021) Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells. Hepatology 74 2170-2185 PMID: 33932306
Yangyang et al (2021) CHPG enhances BDNF and myelination in cuprizone-treated mice through astrocytic metabotropic glutamate receptor 5. Glia 69 1950-1965 PMID: 33811383
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Literature in this Area
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