Chaetoglobosin A

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Cat.No. 5804 - Chaetoglobosin A | C32H36N2O5 | CAS No. 50335-03-0
Description: Antibiotic; selectively induces apoptosis of CLL cells
Chemical Name: (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antibiotic; preferentially induces apoptosis in chronic lymphocytic leukemia (CLL) cells over normal B cells. Inhibits actin polymerization and leads to the accumulation of cells in G2 phase.

Technical Data

M. Wt 528.64
Formula C32H36N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 50335-03-0
PubChem ID 102601376
InChI Key OUMWCYMRLMEZJH-ZDSWJECVSA-N
Smiles [H][C@]12[C@@H](NC([C@]13C(/C=C/C([C@@H](/C(C)=C\[C@H](C/C=C/[C@]3([C@@H]4O[C@@]4([C@H]2C)C)[H])C)O)=O)=O)=O)CC5=CNC6=C5C=CC=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.86 100

Preparing Stock Solutions

The following data is based on the product molecular weight 528.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.46 mL 18.92 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Knudsen et al (2014) Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia 28 1289 PMID: 24280868


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Keywords: Chaetoglobosin A, supplier, Antibiotics, induces, apoptosis, inducer, selective, chronic, lymphocytic, leukemia, CLL, actin, polymerisation, inhibitor, inhbits, Antibiotics, Tocris Bioscience

Citations for Chaetoglobosin A

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Chaetoglobosin A

Protocols

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