Chaetoglobosin A

Pricing Availability   Qty
Description: Antibiotic; selectively induces apoptosis of CLL cells
Chemical Name: (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
Purity: ≥98% (HPLC)
Reviews (1)

Biological Activity for Chaetoglobosin A

Chaetoglobosin A is an antibiotic; preferentially induces apoptosis in chronic lymphocytic leukemia (CLL) cells over normal B cells. Inhibits actin polymerization and leads to the accumulation of cells in G2 phase.

Technical Data for Chaetoglobosin A

M. Wt 528.64
Formula C32H36N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 50335-03-0
PubChem ID 102601376
Smiles O=C1[C@]23[C@]([H])([C@H](CC4=CNC5=CC=CC=C45)N1)[C@H](C)[C@]6(C)[C@]([H])([C@@]2(/C=C/C[C@H](C)/C=C(C)/[C@@H](O)C(/C=C/C3=O)=O)[H])O6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Chaetoglobosin A

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.86 100

Preparing Stock Solutions for Chaetoglobosin A

The following data is based on the product molecular weight 528.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.46 mL 18.92 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for Chaetoglobosin A

References for Chaetoglobosin A

References are publications that support the biological activity of the product.

Knudsen et al (2014) Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia 28 1289 PMID: 24280868

If you know of a relevant reference for Chaetoglobosin A, please let us know.

Keywords: Chaetoglobosin A, Chaetoglobosin A supplier, Antibiotics, induces, apoptosis, inducer, selective, chronic, lymphocytic, leukemia, CLL, actin, polymerisation, inhibitor, inhbits, Apoptosis, Inducers, Actin, 5804, Tocris Bioscience

Citations for Chaetoglobosin A

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Reviews for Chaetoglobosin A

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Apoptotic properties of Chaetoglobosin A was assessed.
By Anonymous on 01/24/2019
Assay Type: In Vitro
Species: Human

Apoptotic properties of Chaetoglobosin A was assessed. Apoptosis triggered by Chaetoglobosin A and DR5 MAb was measured simultaneously.

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