Chaetoglobosin A

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Cat.No. 5804 - Chaetoglobosin A | C32H36N2O5 | CAS No. 50335-03-0
Description: Antibiotic; selectively induces apoptosis of CLL cells
Chemical Name: (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
Purity: ≥98% (HPLC)

Biological Activity

Antibiotic; preferentially induces apoptosis in chronic lymphocytic leukemia (CLL) cells over normal B cells. Inhibits actin polymerization and leads to the accumulation of cells in G2 phase.

Technical Data

M. Wt 528.64
Formula C32H36N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 50335-03-0
PubChem ID 102601376
Smiles [H][C@]12[C@@H](NC([C@]13C(/C=C/C([C@@H](/C(C)=C\[C@H](C/C=C/[C@]3([C@@H]4O[C@@]4([C@H]2C)C)[H])C)O)=O)=O)=O)CC5=CNC6=C5C=CC=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.86 100

Preparing Stock Solutions

The following data is based on the product molecular weight 528.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.46 mL 18.92 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Knudsen et al (2014) Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia 28 1289 PMID: 24280868

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