Selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 329.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.04 mL||15.18 mL||30.36 mL|
|5 mM||0.61 mL||3.04 mL||6.07 mL|
|10 mM||0.3 mL||1.52 mL||3.04 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Buchdunger et al (1994) 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 91 2334 PMID: 8134396
Blanchard et al (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 101 14326 PMID: 15388848
Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 105 7159 PMID: 18480256
If you know of a relevant reference for CGP 52411, please let us know.
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Keywords: abeta42 ab42 aβ42 fibers fibres fibrils epidermal growth factors receptors EGFR Alzheimers disease CGP52411 amyloidbeta amyloidb amyloidβ DAPH EGFR
Citations for CGP 52411
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