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CGP 36216 hydrochloride
Biological Activity for CGP 36216 hydrochloride
CGP 36216 hydrochloride is a selective GABAB antagonist. Displays activity at presynaptic receptors; ineffective at GABAB postsynaptic receptors.
Compound Libraries for CGP 36216 hydrochloride
Technical Data for CGP 36216 hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CGP 36216 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CGP 36216 hydrochloride
The following data is based on the product molecular weight 187.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.33 mL||26.65 mL||53.3 mL|
|5 mM||1.07 mL||5.33 mL||10.66 mL|
|10 mM||0.53 mL||2.67 mL||5.33 mL|
|50 mM||0.11 mL||0.53 mL||1.07 mL|
Product Datasheets for CGP 36216 hydrochloride
References for CGP 36216 hydrochloride
References are publications that support the biological activity of the product.
Ong et al (2001) CGP 36216 is a selective antagonist at GABAB presynaptic receptors in rat brain. Eur.J.Pharmacol. 415 191 PMID: 11274998
Froestl et al (1995) Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J.Med.Chem. 38 3313 PMID: 7650685
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Keywords: CGP 36216 hydrochloride, CGP 36216 hydrochloride supplier, CGP36216, hydrochloride, gabab, antagonists, presynaptic, selective, GABAB, Receptors, 3219, Tocris Bioscience
1 Citation for CGP 36216 hydrochloride
Citations are publications that use Tocris products. Selected citations for CGP 36216 hydrochloride include:
Chen et al (2015) Morphine disinhibits glutamatergic input to VTA DA neurons and promotes DA neuron excitation. J Neurosci 4 PMID: 26208338
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.