CGP 36216 hydrochloride

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Cat.No. 3219 - CGP 36216 hydrochloride | C5H14NO2P.HCl | CAS No. 123691-29-2
Description: GABAB antagonist; displays activity at presynaptic receptors
Chemical Name: (3-Aminopropyl)ethylphosphinic acid hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective GABAB antagonist. Displays activity at presynaptic receptors; ineffective at GABAB postsynaptic receptors.

Technical Data

M. Wt 187.6
Formula C5H14NO2P.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 123691-29-2
PubChem ID 90488815
InChI Key CFQFXUJBWMPODB-UHFFFAOYSA-N
Smiles O=P(CC)(CCCN)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.76 100
water 18.76 100

Preparing Stock Solutions

The following data is based on the product molecular weight 187.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.33 mL 26.65 mL 53.3 mL
5 mM 1.07 mL 5.33 mL 10.66 mL
10 mM 0.53 mL 2.67 mL 5.33 mL
50 mM 0.11 mL 0.53 mL 1.07 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ong et al (2001) CGP 36216 is a selective antagonist at GABAB presynaptic receptors in rat brain. Eur.J.Pharmacol. 415 191 PMID: 11274998

Froestl et al (1995) Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J.Med.Chem. 38 3313 PMID: 7650685


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1 Citation for CGP 36216 hydrochloride

Citations are publications that use Tocris products. Selected citations for CGP 36216 hydrochloride include:

Chen et al (2015) Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. J Neurosci 4 PMID: 26208338


Do you know of a great paper that uses CGP 36216 hydrochloride from Tocris? If so please let us know.

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Pathways for CGP 36216 hydrochloride

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