CGP 36216 hydrochloride

Pricing Availability   Qty
Description: GABAB antagonist; displays activity at presynaptic receptors
Chemical Name: (3-Aminopropyl)ethylphosphinic acid hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for CGP 36216 hydrochloride

CGP 36216 hydrochloride is a selective GABAB antagonist. Displays activity at presynaptic receptors; ineffective at GABAB postsynaptic receptors.

Compound Libraries for CGP 36216 hydrochloride

CGP 36216 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CGP 36216 hydrochloride

M. Wt 187.6
Formula C5H14NO2P.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1781834-71-6
PubChem ID 90488815
Smiles O=P(CC)(CCCN)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CGP 36216 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 18.76 100
DMSO 18.76 100

Preparing Stock Solutions for CGP 36216 hydrochloride

The following data is based on the product molecular weight 187.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.33 mL 26.65 mL 53.3 mL
5 mM 1.07 mL 5.33 mL 10.66 mL
10 mM 0.53 mL 2.67 mL 5.33 mL
50 mM 0.11 mL 0.53 mL 1.07 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for CGP 36216 hydrochloride

References for CGP 36216 hydrochloride

References are publications that support the biological activity of the product.

Ong et al (2001) CGP 36216 is a selective antagonist at GABAB presynaptic receptors in rat brain. Eur.J.Pharmacol. 415 191 PMID: 11274998

Froestl et al (1995) Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J.Med.Chem. 38 3313 PMID: 7650685

If you know of a relevant reference for CGP 36216 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all GABAB Receptor Antagonists

Keywords: CGP 36216 hydrochloride, CGP 36216 hydrochloride supplier, CGP36216, hydrochloride, gabab, antagonists, presynaptic, selective, GABAB, Receptors, 3219, Tocris Bioscience

1 Citation for CGP 36216 hydrochloride

Citations are publications that use Tocris products. Selected citations for CGP 36216 hydrochloride include:

Chen et al (2015) Morphine disinhibits glutamatergic input to VTA DA neurons and promotes DA neuron excitation. J Neurosci 4 PMID: 26208338

Do you know of a great paper that uses CGP 36216 hydrochloride from Tocris? Please let us know.

Reviews for CGP 36216 hydrochloride

There are currently no reviews for this product. Be the first to review CGP 36216 hydrochloride and earn rewards!

Have you used CGP 36216 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.