CGP 3466B maleate

Pricing Availability   Qty
Description: GAPDH inhibitor; neuroprotective
Alternative Names: TCH 346 maleate
Chemical Name: N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)amine maleate
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for CGP 3466B maleate

CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H2O2 release. CGP 3466B inhibits colon cancer proliferation in vitro and displays neuroprotective activity in vivo.

Compound Libraries for CGP 3466B maleate

CGP 3466B maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CGP 3466B maleate

M. Wt 391.42
Formula C19H17NO.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 200189-97-5
PubChem ID 9821821
Smiles O=C(O)/C=C\C(O)=O.CN(CC#C)CC2=CC1=CC=CC=C1OC3=C2C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CGP 3466B maleate

Solvent Max Conc. mg/mL Max Conc. mM
water 3.91 10
DMSO 39.14 100

Preparing Stock Solutions for CGP 3466B maleate

The following data is based on the product molecular weight 391.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.55 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets for CGP 3466B maleate

References for CGP 3466B maleate

References are publications that support the biological activity of the product.

Andringa et al (2003) TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates. Neurobiol.Dis. 14 205 PMID: 14572443

Sagot et al (2000) An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. Br.J.Pharmacol. 131 721 PMID: 11030721

Zoccarato et al (2008) Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H2O2 release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J.Bioenerg.Biomembr. 40 289 PMID: 18763029

Bazzocco et al (2015) Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment. Clin.Cancer Res. 21 3685 PMID: 25944804

If you know of a relevant reference for CGP 3466B maleate, please let us know.

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Keywords: CGP 3466B maleate, CGP 3466B maleate supplier, glyceraldehyde-3-phosphate, dehydrogenase, GAPDH, inhibitors, inhibits, CGP3466B, TCH346, TCH, 346, maleate, Other, Dehydrogenases, 2966, Tocris Bioscience

1 Citation for CGP 3466B maleate

Citations are publications that use Tocris products. Selected citations for CGP 3466B maleate include:

Xu et al (2013) Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. Neuron 78 623 PMID: 23719162

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Literature in this Area

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