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CFM 4

Cat. No. 5144 Submit a Review Datasheet / COA / SDS
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Cat.No. 5144 - CFM 4 | C22H16ClN3OS | CAS No. 331458-02-7
Description: CARP-1 mimetic; proapoptotic
Chemical Name: 1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

CARP-1 mimetic; interferes with CARP-1 binding to APC-2. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses cell growth in cancer cells.

Technical Data

M. Wt 405.9
Formula C22H16ClN3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 331458-02-7
PubChem ID 2871439
InChI Key PMADITKBVODKSF-UHFFFAOYSA-N
Smiles O=C2N(CC4=CC=CC=C4Cl)C1=CC=CC=C1C32NN=C(C5=CC=CC=C5)S3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.12 20

Preparing Stock Solutions

The following data is based on the product molecular weight 405.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.32 mL 61.59 mL 123.18 mL
1 mM 2.46 mL 12.32 mL 24.64 mL
2 mM 1.23 mL 6.16 mL 12.32 mL
10 mM 0.25 mL 1.23 mL 2.46 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Puliyappadamba et al (2011) Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J.Biol.Chem. 286 38000 PMID: 21903591

Ashour et al (2013) CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS ONE 8 e66733 PMID: 23826121

If you know of a relevant reference for CFM 4, please let us know.

View Related Products by Target

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Citations for CFM 4

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for CFM 4

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.