Discontinued Product

CFM 4 (Cat. No. 5144) has been withdrawn from sale for commercial reasons.
Description: CARP-1 mimetic; proapoptotic
Chemical Name: 1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one
Purity: ≥99% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for CFM 4

CFM 4 is a CARP-1 mimetic; interferes with CARP-1 binding to APC-2. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses cell growth in cancer cells.

Technical Data for CFM 4

M. Wt 405.9
Formula C22H16ClN3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 331458-02-7
PubChem ID 2871439
Smiles O=C2N(CC4=CC=CC=C4Cl)C1=CC=CC=C1C32NN=C(C5=CC=CC=C5)S3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CFM 4

References are publications that support the biological activity of the product.

Puliyappadamba et al (2011) Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J.Biol.Chem. 286 38000 PMID: 21903591

Ashour et al (2013) CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS ONE 8 e66733 PMID: 23826121

Keywords: CFM 4, CFM 4 supplier, CFM4, CARP-1, mimetic, proapoptotic, antitumor, antitumorgenic, APC-2, G2M, cell, cycle, arrest, Apoptosis, Inducers, Cell, Cycle, Inhibitors, 5144, Tocris Bioscience

Citations for CFM 4

Citations are publications that use Tocris products.

Currently there are no citations for CFM 4.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for CFM 4

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.