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Biological Activity for CeMMEC1
CeMMEC1 is a TAF1 inhibitor (Kd = 1.8 μM, IC50 = 900 nM). CeMMEC1 impairs cell viability in combination with (+)-JQ1 (Cat. No. 4499) and inhibits proliferation of THP-1 and H23 lung adenocarcinoma cells.
Compound Libraries for CeMMEC1
Technical Data for CeMMEC1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CeMMEC1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CeMMEC1
The following data is based on the product molecular weight 336.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.97 mL||14.87 mL||29.73 mL|
|5 mM||0.59 mL||2.97 mL||5.95 mL|
|10 mM||0.3 mL||1.49 mL||2.97 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
References for CeMMEC1
References are publications that support the biological activity of the product.
Sdelci et al (2016) Mapping the chemical chromatin reactivation landscape identifies BRD 4-TAtaF1 cross-talk. Nat.Chem.Biol. 12 504 PMID: 27159579
If you know of a relevant reference for CeMMEC1, please let us know.
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Keywords: CeMMEC1, CeMMEC1 supplier, TAF1, bromodomain, inhibits, inhibitors, Bromodomains, 7139, Tocris Bioscience
Citations for CeMMEC1
Citations are publications that use Tocris products.
Currently there are no citations for CeMMEC1. Do you know of a great paper that uses CeMMEC1 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases
Epigenetics in Cancer Poster
Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.