Pricing Availability   Qty
Description: TAF1 inhibitor
Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for CeMMEC1

CeMMEC1 is a TAF1 inhibitor (Kd = 1.8 μM, IC50 = 900 nM). CeMMEC1 impairs cell viability in combination with (+)-JQ1 (Cat. No. 4499) and inhibits proliferation of THP-1 and H23 lung adenocarcinoma cells.

Compound Libraries for CeMMEC1

CeMMEC1 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for CeMMEC1

M. Wt 336.35
Formula C19H16N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 440662-09-9
PubChem ID 24152379
Smiles CN1C=C(C(=O)NC2=CC=C3OCCOC3=C2)C2=CC=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CeMMEC1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.63 100

Preparing Stock Solutions for CeMMEC1

The following data is based on the product molecular weight 336.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.87 mL 29.73 mL
5 mM 0.59 mL 2.97 mL 5.95 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References for CeMMEC1

References are publications that support the biological activity of the product.

Sdelci et al (2016) Mapping the chemical chromatin reactivation landscape identifies BRD 4-TAtaF1 cross-talk. Nat.Chem.Biol. 12 504 PMID: 27159579

If you know of a relevant reference for CeMMEC1, please let us know.

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Keywords: CeMMEC1, CeMMEC1 supplier, TAF1, bromodomain, inhibits, inhibitors, Bromodomains, 7139, Tocris Bioscience

Citations for CeMMEC1

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