Ceefourin 1

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Description: Selective MRP4 inhibitor
Chemical Name: 5-[(2-Benzothiazolylthio)methyl]-2,4-dihydro-4-methyl-3H-1,2,4-triazole-3-thione
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Ceefourin 1

Ceefourin 1 is a selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC50 = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 (Cat. No. 2684). Ceefourin 1 inhibits cAMP efflux from acute myeloid leukemia cells (AML) and promotes apoptosis in combination with Histamine (Cat. No. 3545).

Technical Data for Ceefourin 1

M. Wt 294.42
Formula C11H10N4S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 315702-40-0
PubChem ID 704306
Smiles CN1C(NN=C1CSC2=NC3=CC=CC=C3S2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ceefourin 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.44 100

Preparing Stock Solutions for Ceefourin 1

The following data is based on the product molecular weight 294.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.98 mL 33.97 mL
5 mM 0.68 mL 3.4 mL 6.79 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References for Ceefourin 1

References are publications that support the biological activity of the product.

Cheung et al (2014) High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 91 97 PMID: 24973542

Sahores et al (2023) Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine. Biochim.Biophys.Acta 1867 130322 PMID: 36773726

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Keywords: Ceefourin 1, Ceefourin 1 supplier, multidrug, resistance-associated, protein, 4, MRP4, inhibitors, inhibits, transporters, ABCC4, AML, acute, myeloid, leukemia, apoptosis, Multidrug, Transporters, Other, Apoptosis, 5867, Tocris Bioscience

Citations for Ceefourin 1

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Programmed Cell Death Poster

Programmed Cell Death Poster

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