Ceefourin 1

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Cat.No. 5867 - Ceefourin 1 | C11H10N4S3 | CAS No. 315702-40-0
Description: Selective MRP4 inhibitor
Chemical Name: 5-[(2-Benzothiazolylthio)methyl]-2,4-dihydro-4-methyl-3H-1,2,4-triazole-3-thione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC50 = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 (Cat. No. 2684).

Technical Data

M. Wt 294.42
Formula C11H10N4S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 315702-40-0
PubChem ID 704306
InChI Key KVNBVHCJAUXKPJ-UHFFFAOYSA-N
Smiles CN1C(NN=C1CSC2=NC3=CC=CC=C3S2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 294.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.98 mL 33.97 mL
5 mM 0.68 mL 3.4 mL 6.79 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References

References are publications that support the biological activity of the product.

Cheung et al (2014) High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 91 97 PMID: 24973542


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Keywords: Ceefourin 1, Ceefourin 1 supplier, multidrug, resistance-associated, protein, 4, MRP4, inhibitors, inhibits, transporter, Multidrug, Transporters, 5867, Tocris Bioscience

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