SN 38

Pricing Availability   Qty
Description: DNA topoisomerase I inhibitor; antitumor
Alternative Names: 7-Ethyl-10-hydroxycamptothecin
Chemical Name: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
Purity: ≥98% (HPLC)
Datasheet
Citations (10)
Reviews
Literature (2)

Biological Activity for SN 38

SN 38 is an active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

Compound Libraries for SN 38

SN 38 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SN 38

M. Wt 392.4
Formula C22H20N2O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 86639-52-3
PubChem ID 104842
InChI Key FJHBVJOVLFPMQE-QFIPXVFZSA-N
Smiles OC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2CC)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SN 38

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.62 50

Preparing Stock Solutions for SN 38

The following data is based on the product molecular weight 392.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.1 mL 25.48 mL 50.97 mL
2.5 mM 1.02 mL 5.1 mL 10.19 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
25 mM 0.1 mL 0.51 mL 1.02 mL

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Product Datasheets for SN 38

Certificate of Analysis / Product Datasheet
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References for SN 38

References are publications that support the biological activity of the product.

Kawato et al (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 51 4187 PMID: 1651156

Gao et al (2005) Synthesis and antitumor activity of the hexacyclic camptothecin derivatives. Bioorg.Med.Chem.Lett. 15 3233 PMID: 15913996

Koizumi et al (2006) Novel SN-38-incorporating ploymeric micelles, NK012, eradicate vascular endothelial growth factor-Secr.g bulky tumors. Cancer Res. 66 10048 PMID: 17047068


If you know of a relevant reference for SN 38, please let us know.

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Keywords: SN 38, SN 38 supplier, DNA, topoisomerase, I, inhibitors, inhibits, antitumor, Isomerases, SN38, chemotherapeutics, 7-Ethyl-10-hydroxycamptothecin, Topoisomerase, 2684, Tocris Bioscience

10 Citations for SN 38

Citations are publications that use Tocris products. Selected citations for SN 38 include:

Vétillard et al (2015) Akt inhibition improves irino. treatment and prevents cell emergence by switching the senescence response to apoptosis. Exp Neurol 6 43342 PMID: 26485768

Duff et al (2018) Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy. Cell Death Dis 9 199 PMID: 29415991

Wolff et al (2018) Camptothecin exhibits topoisomerase1-independent KMT1A suppression and myogenic differentiation in alveolar rhabdomyosarcoma cells. Oncotarget 9 25796 PMID: 29899822

Guillon et al (2019) Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. Cell Death Dis 10 199 PMID: 30814491


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Reviews for SN 38

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Literature in this Area

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Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.