Histamine dihydrochloride

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Cat.No. 3545 - Histamine dihydrochloride | C5H9N3.2HCl | CAS No. 56-92-8
Description: Endogenous histamine receptor agonist
Chemical Name: 2-(4-Imidazolyl)ethylamine dihydrochloride
Datasheet
Citations (4)
Reviews (1)
Literature

Biological Activity

Endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.

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Technical Data

M. Wt 184.07
Formula C5H9N3.2HCl
Storage Desiccate at RT
CAS Number 56-92-8
PubChem ID 5818
InChI Key PPZMYIBUHIPZOS-UHFFFAOYSA-N
Smiles NCCC1=CNC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.41 100
DMSO 18.41 100

Preparing Stock Solutions

The following data is based on the product molecular weight 184.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.43 mL 27.16 mL 54.33 mL
5 mM 1.09 mL 5.43 mL 10.87 mL
10 mM 0.54 mL 2.72 mL 5.43 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

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References

References are publications that support the biological activity of the product.

Hill et al (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 49 253 PMID: 9311023

Thurmond et al (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 7 41 PMID: 18172439

Maintz and Novak (2007) Histamine and histamine intolerance. Am.J.Clin.Nutr. 85 1185 PMID: 17490952


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View Related Products by Product Action

View all Histamine H1 Receptor Agonists

Keywords: Histamine dihydrochloride, Histamine dihydrochloride supplier, Endogenous, histamine, receptor, agonists, H4, Receptors, Histamine, H1, H2, H3, histaminergic, 3545, Tocris Bioscience

4 Citations for Histamine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Histamine dihydrochloride include:

Femenia et al (2015) Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. Int J Neuropsychopharmacol 18 PMID: 25762718

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

Melchior and Frangos (2012) Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Acta Pharmacol Sin 303 C467 PMID: 22700794

Chen et al (2017) Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop. Cell Stem Cell 21 747 PMID: 29198940


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Reviews for Histamine dihydrochloride

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Histamine releases Ca2+ from ER stores in EA.hy926 cells..
By Niroj Shrestha on 12/04/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: EA.hy926

EA.hy926 cells were loaded with cytosolic Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm. ER Ca2+ store was depleted with 100 µM histamine in 0.1 mM EGTA-tyrode solution, resulting in transient cytosolic Ca2+ peak.

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