Histamine dihydrochloride

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Cat.No. 3545 - Histamine dihydrochloride | C5H9N3.2HCl | CAS No. 56-92-8
Description: Endogenous histamine receptor agonist
Chemical Name: 2-(4-Imidazolyl)ethylamine dihydrochloride
Citations (3)

Biological Activity

Endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.

Compound Libraries

Histamine dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 184.07
Formula C5H9N3.2HCl
Storage Desiccate at RT
CAS Number 56-92-8
PubChem ID 5818
Smiles NCCC1=CNC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.41 100
water 18.41 100

Preparing Stock Solutions

The following data is based on the product molecular weight 184.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.43 mL 27.16 mL 54.33 mL
5 mM 1.09 mL 5.43 mL 10.87 mL
10 mM 0.54 mL 2.72 mL 5.43 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hill et al (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 49 253 PMID: 9311023

Thurmond et al (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 7 41 PMID: 18172439

Maintz and Novak (2007) Histamine and histamine intolerance. Am.J.Clin.Nutr. 85 1185 PMID: 17490952

If you know of a relevant reference for Histamine dihydrochloride, please let us know.

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Keywords: Endogenous histamine receptor agonists H4 Receptors Histamine H1 H2 H3 histaminergic Histamine H1 Receptors

3 Citations for Histamine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Histamine dihydrochloride include:

Femenia et al (2015) Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. Int J Neuropsychopharmacol 18 PMID: 25762718

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

Melchior and Frangos (2012) Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Acta Pharmacol Sin 303 C467 PMID: 22700794

Do you know of a great paper that uses Histamine dihydrochloride from Tocris? If so please let us know.

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Literature in this Area


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Pathways for Histamine dihydrochloride


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