Histamine dihydrochloride

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Description: Endogenous histamine receptor agonist
Chemical Name: 2-(4-Imidazolyl)ethylamine dihydrochloride
Citations (9)
Reviews (1)
Literature (1)

Biological Activity for Histamine dihydrochloride

Histamine dihydrochloride is an endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.

Compound Libraries for Histamine dihydrochloride

Histamine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Histamine dihydrochloride

M. Wt 184.07
Formula C5H9N3.2HCl
Storage Desiccate at RT
CAS Number 56-92-8
PubChem ID 5818
Smiles NCCC1=CNC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Histamine dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 18.41 100
DMSO 18.41 100

Preparing Stock Solutions for Histamine dihydrochloride

The following data is based on the product molecular weight 184.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.43 mL 27.16 mL 54.33 mL
5 mM 1.09 mL 5.43 mL 10.87 mL
10 mM 0.54 mL 2.72 mL 5.43 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

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Product Datasheets for Histamine dihydrochloride

Certificate of Analysis / Product Datasheet
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References for Histamine dihydrochloride

References are publications that support the biological activity of the product.

Hill et al (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 49 253 PMID: 9311023

Thurmond et al (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 7 41 PMID: 18172439

Maintz and Novak (2007) Histamine and histamine intolerance. Am.J.Clin.Nutr. 85 1185 PMID: 17490952

If you know of a relevant reference for Histamine dihydrochloride, please let us know.

View Related Products by Product Action

View all Histamine H1 Receptor Agonists

Keywords: Histamine dihydrochloride, Histamine dihydrochloride supplier, Endogenous, histamine, receptor, agonists, H4, Receptors, Histamine, H1, H2, H3, histaminergic, 3545, Tocris Bioscience

9 Citations for Histamine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Histamine dihydrochloride include:

JoAnn et al (2019) G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells. J Biol Chem 294 5867-5878 PMID: 30760523

Hao et al (2019) A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron 102 745-761.e8 PMID: 30922875

Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084

Chen et al (2017) Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop. Cell Stem Cell 21 747 PMID: 29198940

Do you know of a great paper that uses Histamine dihydrochloride from Tocris? Please let us know.

Reviews for Histamine dihydrochloride

Average Rating: 4 (Based on 1 Review.)

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Histamine releases Ca2+ from ER stores in EA.hy926 cells..
By Niroj Shrestha on 12/04/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: EA.hy926

EA.hy926 cells were loaded with cytosolic Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm. ER Ca2+ store was depleted with 100 µM histamine in 0.1 mM EGTA-tyrode solution, resulting in transient cytosolic Ca2+ peak.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.