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CCT 031374 hydrobromide
Inhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 434.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.6 mL||23.02 mL||46.05 mL|
|2.5 mM||0.92 mL||4.6 mL||9.21 mL|
|5 mM||0.46 mL||2.3 mL||4.6 mL|
|25 mM||0.09 mL||0.46 mL||0.92 mL|
References are publications that support the biological activity of the product.
Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963 PMID: 20610623
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Keywords: CCT 031374 hydrobromide, CCT 031374 hydrobromide supplier, CCT031374, hydrobromide, TCF, transcription, inhibitors, inhibits, beta-catenin, b-catenin, β-catenin, stabilization, Beta-catenin, 4675, Tocris Bioscience
2 Citations for CCT 031374 hydrobromide
Citations are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:
Brown et al (2019) Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells. Aging Cell 18 e12844 PMID: 30548452
Liu et al (2015) β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Nature 36 1572 PMID: 26496941
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Literature in this Area
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