CCT 031374 hydrobromide

Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Description: Inhibits TCF-dependent transcription; lowers β-catenin levels
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide
Purity: ≥98% (HPLC)
Citations (2)
Literature (1)
Pathways (1)

Biological Activity for CCT 031374 hydrobromide

CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.

Technical Data for CCT 031374 hydrobromide

M. Wt 434.33
Formula C23H19N3O.HBr
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1219184-91-4
PubChem ID 18554738
Smiles O=C(C4=CC=C(C5=CC=CC=C5)C=C4)CN1C3=C(C=CC=C3)N2C1=NCC2.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CCT 031374 hydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.72 50

Preparing Stock Solutions for CCT 031374 hydrobromide

The following data is based on the product molecular weight 434.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.6 mL 23.02 mL 46.05 mL
2.5 mM 0.92 mL 4.6 mL 9.21 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for CCT 031374 hydrobromide

References for CCT 031374 hydrobromide

References are publications that support the biological activity of the product.

Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963 PMID: 20610623

If you know of a relevant reference for CCT 031374 hydrobromide, please let us know.

View Related Products by Target

Keywords: CCT 031374 hydrobromide, CCT 031374 hydrobromide supplier, CCT031374, hydrobromide, TCF, transcription, inhibitors, inhibits, beta-catenin, b-catenin, β-catenin, stabilization, Beta-catenin, 4675, Tocris Bioscience

2 Citations for CCT 031374 hydrobromide

Citations are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:

Brown et al (2019) Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells. Aging Cell 18 e12844 PMID: 30548452

Liu et al (2015) β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Nature 36 1572 PMID: 26496941

Do you know of a great paper that uses CCT 031374 hydrobromide from Tocris? Please let us know.

Reviews for CCT 031374 hydrobromide

There are currently no reviews for this product. Be the first to review CCT 031374 hydrobromide and earn rewards!

Have you used CCT 031374 hydrobromide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for CCT 031374 hydrobromide

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.