CCT 031374 hydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 4675 - CCT 031374 hydrobromide | C23H19N3O.HBr | CAS No. 1219184-91-4
Description: Inhibits TCF-dependent transcription; lowers β-catenin levels
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Inhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.

Compound Libraries

CCT 031374 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 434.33
Formula C23H19N3O.HBr
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1219184-91-4
PubChem ID 18554738
InChI Key MPILENOYNNNGKO-UHFFFAOYSA-N
Smiles O=C(C4=CC=C(C5=CC=CC=C5)C=C4)CN1C3=C(C=CC=C3)N2C1=NCC2.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 434.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963 PMID: 20610623


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View Related Products by Target

Keywords: CCT031374 hydrobromide TCF transcription inhibitors inhibits beta-catenin b-catenin β-catenin stabilization Beta-catenin

1 Citation for CCT 031374 hydrobromide

Citations are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:

Liu et al (2015) β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Nature 36 1572 PMID: 26496941


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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for CCT 031374 hydrobromide

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.

Protocols

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