Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: High affinity and subtype-selective α6β2 and α4β2 nAChR partial agonist
Chemical Name: (1R,5S)-1,2,3,4,5,6-Hexahydro-3-[2-[(1R,5S)-1,5,6,8-tetrahydro-8-oxo-1,5-methano-2H-pyrido[1,2-a][1,5]diazocin-3(4H)-yl]ethyl]-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for CC4

CC4 is a high affinity and subtype selective α6β2 and α4β2 partial agonist (Ki values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (Ki values are 4.8 and 13 μM for human α3β4 and rat α7 receptors respectively). Stimulates dopamine release from striatal slices in vitro. Attenuates nicotine-induced self-administration and conditional place preference in rats.

Technical Data for CC4

M. Wt 406.52
Formula C24H30N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 492-02-4
PubChem ID 91654624
Smiles O=C1N2C([C@@](C3)([H])CN(CCN5C[C@](C6)([H])C(N4C[C@]6([H])C5)=CC=CC4=O)C[C@@]3([H])C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CC4

Solvent Max Conc. mg/mL Max Conc. mM
water 8.13 20
DMSO 40.65 100

Preparing Stock Solutions for CC4

The following data is based on the product molecular weight 406.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for CC4

References are publications that support the biological activity of the product.

Sala et al (2013) CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking c Br.J.Pharmacol. 168 835 PMID: 22957729

Riganti et al (2005) Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. Br.J.Pharmacol. 146 1096 PMID: 16273122

Carbonnelle et al (2003) Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes. Eur.J.Pharmacol. 471 85 PMID: 12818695

If you know of a relevant reference for CC4, please let us know.

View Related Products by Product Action

View all Nicotinic (α4β2) Receptor Agonists

Keywords: CC4, CC4 supplier, CC4, high, affinity, subtype, selective, partial, agonist, acetylcholine, nicotinic, receptors, alpha4beta2, a4b2, α4β2, alpha6beta3, a6b3, α6β3, Nicotinic, (a4b2), Receptors, (Other, Subtypes), 5236, Tocris Bioscience

1 Citation for CC4

Citations are publications that use Tocris products. Selected citations for CC4 include:

Yi et al (2022) Targeting thalamic circuits rescues motor and mood deficits in PD mice. Nature 607 321-329 PMID: 35676479

Do you know of a great paper that uses CC4 from Tocris? Please let us know.

Reviews for CC4

There are currently no reviews for this product. Be the first to review CC4 and earn rewards!

Have you used CC4?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.