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Biological Activity for Capecitabine
Capecitabine is a prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.
Compound Libraries for Capecitabine
Technical Data for Capecitabine
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Capecitabine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Capecitabine
The following data is based on the product molecular weight 359.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.78 mL||13.91 mL||27.83 mL|
|5 mM||0.56 mL||2.78 mL||5.57 mL|
|10 mM||0.28 mL||1.39 mL||2.78 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References for Capecitabine
References are publications that support the biological activity of the product.
Shimma et al (2000) The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine. Bioorg.Med.Chem.Lett. 8 1697 PMID: 10976516
Desmoulin et al (2002) Metabolism of capecitabine, an oral fluorou. prodrug: 19F NMR studies in animal models and human urine. Drug Metab.Dispos. 30 1221 PMID: 12386128
Bhuyan et al (1972) Cell cycle phase specificity of antitumor agents. Cancer Res. 32 398 PMID: 4258018
If you know of a relevant reference for Capecitabine, please let us know.
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Citations for Capecitabine
Citations are publications that use Tocris products.
Currently there are no citations for Capecitabine. Do you know of a great paper that uses Capecitabine from Tocris? Please let us know.
Reviews for Capecitabine
Average Rating: 5 (Based on 1 Review.)
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Capecitabine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
Literature in this Area
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