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Description: Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis
Alternative Names: Ro 09-1978
Chemical Name: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
Purity: ≥98% (HPLC)
Reviews (1)
Literature (3)

Biological Activity for Capecitabine

Capecitabine is a prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.

Compound Libraries for Capecitabine

Capecitabine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Capecitabine

M. Wt 359.35
Formula C15H22FN3O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 154361-50-9
PubChem ID 60953
Smiles C[C@H]1O[C@@H](N2C=C(F)C(NC(OCCCCC)=O)=NC2=O)[C@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Capecitabine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.94 100
ethanol 35.94 100

Preparing Stock Solutions for Capecitabine

The following data is based on the product molecular weight 359.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.83 mL
5 mM 0.56 mL 2.78 mL 5.57 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for Capecitabine

Certificate of Analysis / Product Datasheet
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References for Capecitabine

References are publications that support the biological activity of the product.

Shimma et al (2000) The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine. Bioorg.Med.Chem.Lett. 8 1697 PMID: 10976516

Desmoulin et al (2002) Metabolism of capecitabine, an oral fluorou. prodrug: 19F NMR studies in animal models and human urine. Drug Metab.Dispos. 30 1221 PMID: 12386128

Bhuyan et al (1972) Cell cycle phase specificity of antitumor agents. Cancer Res. 32 398 PMID: 4258018

If you know of a relevant reference for Capecitabine, please let us know.

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Citations for Capecitabine

Citations are publications that use Tocris products.

Currently there are no citations for Capecitabine. Do you know of a great paper that uses Capecitabine from Tocris? Please let us know.

Reviews for Capecitabine

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Medium concentrations of capecitabine only weakly slow melanoma growth in vitro.
By Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human

Capecitabine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

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Literature in this Area

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