Prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 359.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.78 mL||13.91 mL||27.83 mL|
|5 mM||0.56 mL||2.78 mL||5.57 mL|
|10 mM||0.28 mL||1.39 mL||2.78 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References are publications that support the biological activity of the product.
Shimma et al (2000) The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine. Bioorg.Med.Chem.Lett. 8 1697 PMID: 10976516
Desmoulin et al (2002) Metabolism of capecitabine, an oral fluorouracil prodrug: 19F NMR studies in animal models and human urine. Drug Metab.Dispos. 30 1221 PMID: 12386128
Bhuyan et al (1972) Cell cycle phase specificity of antitumor agents. Cancer Res. 32 398 PMID: 4258018
If you know of a relevant reference for Capecitabine, please let us know.
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