Prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 359.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.78 mL||13.91 mL||27.83 mL|
|5 mM||0.56 mL||2.78 mL||5.57 mL|
|10 mM||0.28 mL||1.39 mL||2.78 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Shimma et al (2000) The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine. Bioorg.Med.Chem.Lett. 8 1697 PMID: 10976516
Desmoulin et al (2002) Metabolism of capecitabine, an oral fluorouracil prodrug: 19F NMR studies in animal models and human urine. Drug Metab.Dispos. 30 1221 PMID: 12386128
Bhuyan et al (1972) Cell cycle phase specificity of antitumor agents. Cancer Res. 32 398 PMID: 4258018
If you know of a relevant reference for Capecitabine, please let us know.
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Keywords: 5-Fluorouracil prodrugs 5-FU DNA synthesis inhibitors inhibits inhbits anticancer Ro09-1978 chemotherapeutics Ro 09-1978 DNA, RNA and Protein Synthesis
Citations for Capecitabine
Citations are publications that use Tocris products.
Currently there are no citations for Capecitabine. Do you know of a great paper that uses Capecitabine from Tocris? If so please let us know.