Canrenone

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Cat.No. 3281 - Canrenone | C22H28O3 | CAS No. 976-71-6
Description: Mineralocorticoid receptor antagonist
Chemical Name: (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Mineralocorticoid receptor antagonist. Active metabolite of spironolactone (Cat. No. 2968).

Technical Data

M. Wt 340.46
Formula C22H28O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 976-71-6
PubChem ID 13789
InChI Key UJVLDDZCTMKXJK-WNHSNXHDSA-N
Smiles O=C1CC[C@@]2(C)C(C=C[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 340.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.37 mL
5 mM 0.59 mL 2.94 mL 5.87 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408 PMID: 10760075


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Keywords: Canrenone, Canrenone supplier, Mineralocorticoid, receptor, antagonists, Aldosterone, Receptors, Receptor, 3281, Tocris Bioscience

1 Citation for Canrenone

Citations are publications that use Tocris products. Selected citations for Canrenone include:

Verma et al (2016) Spironolactone blocks Epstein-Barr virus production by inhibiting EBV SM protein function. Proc Natl Acad Sci U S A 113 3609 PMID: 26976570


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