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Submit ReviewCalcineurin Autoinhibitory Peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).
M. Wt | 2930.34 |
Formula | C124H205N39O39S2 |
Sequence | ITSFEEAKGLDRINERMPPRRDAMP |
Storage | Desiccate at -20°C |
CAS Number | 148067-21-4 |
PubChem ID | 90488720 |
InChI Key | JRQDGUSHUYLSHC-TVQDNDAUSA-N |
Smiles | [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Hashimoto et al (1990) Identification of an autoinhibitory domain in calcineurin. J.Biol.Chem. 265 1924 PMID: 2153670
Perrino et al (1995) Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J.Biol.Chem. 270 340 PMID: 7814394
Yokoyama and Wang (1994) The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase. FEBS Lett. 337 128 PMID: 8287965
Keywords: Calcineurin autoinhibitory peptide, Calcineurin autoinhibitory peptide supplier, Selective, calcineurin, inhibitors, inhibits, Protein, Ser/Thr, Phosphatases, Autoinhibitory, peptide, 457-482, NFAT, 1891, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Calcineurin Autoinhibitory Peptide include:
Rashki et al (2019) Cyclosporin A attenuating MOR tolerance through inhibiting NO/ERK signaling pathway in human glioblastoma cell line: the involvement of calcineurin. EXCLI J 17 1137 PMID: 30713473
Krenz et al (2015) Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin. PLoS One 10 e0117965 PMID: 25692473
Biou et al (2008) Endocytosis and recycling of AMPA receptors lacking GluR2/3. J Pharmacol Exp Ther 105 1038 PMID: 18195348
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