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Calcineurin Autoinhibitory Peptide

Cat. No. 1891 3 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

Calcineurin Autoinhibitory Peptide (Cat. No. 1891) has been withdrawn from sale for commercial reasons.
Description: Selective calcineurin inhibitor
Alternative Names: Autoinhibitory peptide 457-482
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Calcineurin Autoinhibitory Peptide

Calcineurin Autoinhibitory Peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).

Technical Data for Calcineurin Autoinhibitory Peptide

M. Wt 2930.34
Formula C124H205N39O39S2
Sequence ITSFEEAKGLDRINERMPPRRDAMP
Storage Desiccate at -20°C
CAS Number 148067-21-4
PubChem ID 90488720
InChI Key JRQDGUSHUYLSHC-TVQDNDAUSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Calcineurin Autoinhibitory Peptide

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References for Calcineurin Autoinhibitory Peptide

References are publications that support the biological activity of the product.

Hashimoto et al (1990) Identification of an autoinhibitory domain in calcineurin. J.Biol.Chem. 265 1924 PMID: 2153670

Perrino et al (1995) Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J.Biol.Chem. 270 340 PMID: 7814394

Yokoyama and Wang (1994) The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase. FEBS Lett. 337 128 PMID: 8287965

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Keywords: Calcineurin autoinhibitory peptide, Calcineurin autoinhibitory peptide supplier, Selective, calcineurin, inhibitors, inhibits, Protein, Ser/Thr, Phosphatases, Autoinhibitory, peptide, 457-482, NFAT, 1891, Tocris Bioscience

3 Citations for Calcineurin Autoinhibitory Peptide

Citations are publications that use Tocris products. Selected citations for Calcineurin Autoinhibitory Peptide include:

Biou et al (2008) Endocytosis and recycling of AMPA receptors lacking GluR2/3. J Pharmacol Exp Ther 105 1038 PMID: 18195348

Rashki et al (2019) Cyclosporin A attenuating MOR tolerance through inhibiting NO/ERK signaling pathway in human glioblastoma cell line: the involvement of calcineurin. EXCLI J 17 1137 PMID: 30713473

Krenz et al (2015) Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin. PLoS One 10 e0117965 PMID: 25692473

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