Calcineurin Autoinhibitory Peptide

Pricing Availability Delivery Time Qty
Cat.No. 1891 - Calcineurin autoinhibitory peptide | Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro | CAS No. 148067-21-4
Description: Selective calcineurin inhibitor
Alternative Names: Autoinhibitory peptide 457-482
Datasheet
Citations (2)
Literature

Biological Activity

Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).

Technical Data

M. Wt 2930.34
Formula C124H205N39O39S2
Sequence ITSFEEAKGLDRINERMPPRRDAMP
Storage Desiccate at -20°C
CAS Number 148067-21-4
PubChem ID 90488720
InChI Key JRQDGUSHUYLSHC-TVQDNDAUSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2930.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.34 mL 1.71 mL 3.41 mL
5 mM 0.07 mL 0.34 mL 0.68 mL
10 mM 0.03 mL 0.17 mL 0.34 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hashimoto et al (1990) Identification of an autoinhibitory domain in calcineurin. J.Biol.Chem. 265 1924 PMID: 2153670

Perrino et al (1995) Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J.Biol.Chem. 270 340 PMID: 7814394

Yokoyama and Wang (1994) The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase. FEBS Lett. 337 128 PMID: 8287965


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Keywords: Calcineurin autoinhibitory peptide, supplier, Selective, calcineurin, inhibitors, inhibits, Protein, Ser/Thr, Phosphatases, Autoinhibitory, peptide, 457-482, Autoinhibitory, peptide, 457-482, Protein, Ser/Thr, Phosphatases, NFAT, Protein, Ser/Thr, Phosphatases, Tocris Bioscience

2 Citations for Calcineurin Autoinhibitory Peptide

Citations are publications that use Tocris products. Selected citations for Calcineurin Autoinhibitory Peptide include:

Krenz et al (2015) Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin. PLoS One 10 e0117965 PMID: 25692473

Biou et al (2008) Endocytosis and recycling of AMPA receptors lacking GluR2/3. J Pharmacol Exp Ther 105 1038 PMID: 18195348


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