Home / Pharmacology / Enzymes / Phosphatases / Protein Ser/Thr Phosphatases / Protein Ser/Thr Phosphatases Inhibitors / Calcineurin Autoinhibitory Peptide

Calcineurin Autoinhibitory Peptide

Cat. No. 1891 3 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

Calcineurin Autoinhibitory Peptide (Cat. No. 1891) has been withdrawn from sale for commercial reasons.
Description: Selective calcineurin inhibitor
Alternative Names: Autoinhibitory peptide 457-482
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Calcineurin Autoinhibitory Peptide

Calcineurin Autoinhibitory Peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).

Technical Data for Calcineurin Autoinhibitory Peptide

M. Wt 2930.34
Formula C124H205N39O39S2
Sequence ITSFEEAKGLDRINERMPPRRDAMP
Storage Desiccate at -20°C
CAS Number 148067-21-4
PubChem ID 90488720
InChI Key JRQDGUSHUYLSHC-TVQDNDAUSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Calcineurin Autoinhibitory Peptide

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet is currently unavailable on-line.
Please contact Customer Service.

References for Calcineurin Autoinhibitory Peptide

References are publications that support the biological activity of the product.

Hashimoto et al (1990) Identification of an autoinhibitory domain in calcineurin. J.Biol.Chem. 265 1924 PMID: 2153670

Perrino et al (1995) Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J.Biol.Chem. 270 340 PMID: 7814394

Yokoyama and Wang (1994) The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase. FEBS Lett. 337 128 PMID: 8287965

View Related Products by Target

View Related Products by Product Action

View all Protein Ser/Thr Phosphatases Inhibitors

Keywords: Calcineurin autoinhibitory peptide, Calcineurin autoinhibitory peptide supplier, Selective, calcineurin, inhibitors, inhibits, Protein, Ser/Thr, Phosphatases, Autoinhibitory, peptide, 457-482, NFAT, 1891, Tocris Bioscience

3 Citations for Calcineurin Autoinhibitory Peptide

Citations are publications that use Tocris products. Selected citations for Calcineurin Autoinhibitory Peptide include:

Rashki et al (2019) Cyclosporin A attenuating MOR tolerance through inhibiting NO/ERK signaling pathway in human glioblastoma cell line: the involvement of calcineurin. EXCLI J 17 1137 PMID: 30713473

Krenz et al (2015) Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin. PLoS One 10 e0117965 PMID: 25692473

Biou et al (2008) Endocytosis and recycling of AMPA receptors lacking GluR2/3. J Pharmacol Exp Ther 105 1038 PMID: 18195348

Reviews for Calcineurin Autoinhibitory Peptide

There are currently no reviews for this product. Be the first to review Calcineurin Autoinhibitory Peptide and earn rewards!

Have you used Calcineurin Autoinhibitory Peptide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis