Caffeic acid-pYEEIE

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Cat.No. 1935 - Caffeic acid-pYEEIE | N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr-α-Glu-α-Glu-Ile-Glu | CAS No. 507471-72-9
Description: Phosphopeptide ligand for src SH2 domain
Chemical Name: N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid
Citations (1)
Literature (3)

Biological Activity for Caffeic acid-pYEEIE

Caffeic acid-pYEEIE is a phosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).

Technical Data for Caffeic acid-pYEEIE

M. Wt 923.82
Formula C39H50N5O19P
Sequence YEEIE

(Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr, Glu-2 = αGlu, Glu-3 = αGlu)

Storage Desiccate at -20°C
CAS Number 507471-72-9
PubChem ID 90488727
Smiles CCC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(=O)\C=C\C1=CC=C(O)C(O)=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Caffeic acid-pYEEIE

Certificate of Analysis is currently unavailable on-line.
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References for Caffeic acid-pYEEIE

References are publications that support the biological activity of the product.

Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360

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Keywords: Caffeic acid-pYEEIE, Caffeic acid-pYEEIE supplier, Phosphopeptide, ligands, src, SH2, domain, Kinases, Src, 1935, Tocris Bioscience

1 Citation for Caffeic acid-pYEEIE

Citations are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:

Xie et al (2015) A selective NMR probe to monitor the conformational transition from inactive to active kinase. J Neurosci 10 262 PMID: 25248068

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Literature in this Area

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