Caffeic acid-pYEEIE

Cat. No. 1935 1 Citation Submit a Review Datasheet / COA / SDS

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Cat.No. 1935 - Caffeic acid-pYEEIE | N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr-α-Glu-α-Glu-Ile-Glu | CAS No. 507471-72-9

Description: Phosphopeptide ligand for src SH2 domain

Chemical Name: N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid

Datasheet

Citations (1)

Reviews

Literature (3)

Biological Activity Technical Data Datasheets References

Biological Activity for Caffeic acid-pYEEIE

Caffeic acid-pYEEIE is a phosphopeptide ligand for the src SH2 domain (IC₅₀ = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).

Technical Data for Caffeic acid-pYEEIE

M. Wt	923.82
Formula	C₃₉H₅₀N₅O₁₉P
Sequence	YEEIE (Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr, Glu-2 = αGlu, Glu-3 = αGlu)
Storage	Desiccate at -20°C
CAS Number	507471-72-9
PubChem ID	90488727
InChI Key	OLKLXQPYJYPETQ-GYHHIBSGSA-N
Smiles	CCC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(=O)\C=C\C1=CC=C(O)C(O)=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Caffeic acid-pYEEIE

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Safety Datasheet

References for Caffeic acid-pYEEIE

References are publications that support the biological activity of the product.

Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360

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Keywords: Caffeic acid-pYEEIE, Caffeic acid-pYEEIE supplier, Phosphopeptide, ligands, src, SH2, domain, Kinases, Src, 1935, Tocris Bioscience

1 Citation for Caffeic acid-pYEEIE

Citations are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:

Xie et al (2015) A selective NMR probe to monitor the conformational transition from inactive to active kinase. J Neurosci 10 262 PMID: 25248068

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