Caffeic acid-pYEEIE

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Cat.No. 1935 - Caffeic acid-pYEEIE | N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr-α-Glu-α-Glu-Ile-Glu | CAS No. 507471-72-9
Description: Phosphopeptide ligand for src SH2 domain
Chemical Name: N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid
Datasheet
Citations (1)
Literature

Biological Activity

Phosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).

Technical Data

M. Wt 923.82
Formula C39H50N5O19P
Sequence YEEIE

(Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr, Glu-2 = αGlu, Glu-3 = αGlu)

Storage Desiccate at -20°C
CAS Number 507471-72-9
PubChem ID 90488727
InChI Key OLKLXQPYJYPETQ-GYHHIBSGSA-N
Smiles CCC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(=O)\C=C\C1=CC=C(O)C(O)=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 923.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.08 mL 5.41 mL 10.82 mL
5 mM 0.22 mL 1.08 mL 2.16 mL
10 mM 0.11 mL 0.54 mL 1.08 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet

References

References are publications that support the products' biological activity.

Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360


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Keywords: Caffeic acid-pYEEIE, supplier, Phosphopeptide, ligands, src, SH2, domain, Kinases, Src, Kinases, Src, Kinases, Tocris Bioscience

1 Citation for Caffeic acid-pYEEIE

Citations are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:

Xie et al (2015) A selective NMR probe to monitor the conformational transition from inactive to active kinase. J Neurosci 10 262 PMID: 25248068


Do you know of a great paper that uses Caffeic acid-pYEEIE from Tocris? If so please let us know.

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