Caffeic acid-pYEEIE
![Cat.No. 1935 - Caffeic acid-pYEEIE | N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr-α-Glu-α-Glu-Ile-Glu | CAS No. 507471-72-9](http://resources.tocris.com/images/datasheets/structures/caffeic-acid-pyeeie_1935.png "Cat.No. 1935 - Caffeic acid-pYEEIE | N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr-α-Glu-α-Glu-Ile-Glu | CAS No. 507471-72-9")
Biological Activity
Phosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).
Technical Data
| M. Wt | 923.82 |
| Formula | C39H50N5O19P |
| Sequence |
YEEIE (Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr, Glu-2 = αGlu, Glu-3 = αGlu) |
| Storage | Desiccate at -20°C |
| CAS Number | 507471-72-9 |
| PubChem ID | 90488727 |
| InChI Key | OLKLXQPYJYPETQ-GYHHIBSGSA-N |
| Smiles | CCC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(=O)\C=C\C1=CC=C(O)C(O)=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 923.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.08 mL | 5.41 mL | 10.82 mL |
| 5 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 10 mM | 0.11 mL | 0.54 mL | 1.08 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
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Product Datasheets
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References
References are publications that support the products' biological activity.
Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360
If you know of a relevant reference for Caffeic acid-pYEEIE, please let us know.
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Keywords: Phosphopeptide ligands src SH2 domain Kinases Src Kinases
1 Citation for Caffeic acid-pYEEIE
Citations are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:
Xie et al (2015) A selective NMR probe to monitor the conformational transition from inactive to active kinase. J Neurosci 10 262 PMID: 25248068
Do you know of a great paper that uses Caffeic acid-pYEEIE from Tocris? If so please let us know.
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