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Caffeic acid-pYEEIE

Cat. No. 1935 1 Citation Datasheet / COA / SDS
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Cat.No. 1935 - Caffeic acid-pYEEIE | N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr-α-Glu-α-Glu-Ile-Glu | CAS No. 507471-72-9
Description: Phosphopeptide ligand for src SH2 domain
Chemical Name: N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid
Datasheet
Citations (1)
Reviews
Literature
Biological Activity Technical Data Datasheets References

Biological Activity

Phosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).

Technical Data

M. Wt 923.82
Formula C39H50N5O19P
Sequence YEEIE

(Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr, Glu-2 = αGlu, Glu-3 = αGlu)
Storage Desiccate at -20°C
CAS Number 507471-72-9
PubChem ID 90488727
InChI Key OLKLXQPYJYPETQ-GYHHIBSGSA-N
Smiles CCC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(=O)\C=C\C1=CC=C(O)C(O)=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

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References

References are publications that support the products' biological activity.

Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360

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Keywords: Caffeic acid-pYEEIE, supplier, Phosphopeptide, ligands, src, SH2, domain, Kinases, Src, Kinases, Src, Kinases, Tocris Bioscience

1 Citation for Caffeic acid-pYEEIE

Citations are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:

Xie et al (2015) A selective NMR probe to monitor the conformational transition from inactive to active kinase. J Neurosci 10 262 PMID: 25248068

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