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Biological Activity for Caffeic acid-pYEEIE
Caffeic acid-pYEEIE is a phosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).
Technical Data for Caffeic acid-pYEEIE
(Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr, Glu-2 = αGlu, Glu-3 = αGlu)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Caffeic acid-pYEEIE
References for Caffeic acid-pYEEIE
References are publications that support the biological activity of the product.
Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360
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Keywords: Caffeic acid-pYEEIE, Caffeic acid-pYEEIE supplier, Phosphopeptide, ligands, src, SH2, domain, Kinases, Src, 1935, Tocris Bioscience
1 Citation for Caffeic acid-pYEEIE
Citations are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:
Xie et al (2015) A selective NMR probe to monitor the conformational transition from inactive to active kinase. J Neurosci 10 262 PMID: 25248068
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Literature in this Area
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