Home / Pharmacology / Enzymes / Kinases / Src Kinases / Src Kinase Ligands / N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Cat. No. 1927 Submit a Review Datasheet / COA / SDS

Discontinued Product

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Cat. No. 1927) has been withdrawn from sale for commercial reasons.
Description: Phosphopeptide ligand for src SH2 domain
Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu is a phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.

Technical Data

M. Wt 803.71
Formula C32H46N5O17P
Sequence YEEIE

(Modifications: Tyr-1 = pTyr with C-terminal Ac)
Storage Desiccate at -20°C
CAS Number 159439-02-8
PubChem ID 42628614
InChI Key QQEKQSBIEKQXQS-PSCZMIBCSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet is currently unavailable on-line.
Please contact Customer Service.

References

References are publications that support the biological activity of the product.

Gilmer et al (1994) Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 269 31711 PMID: 7527393

Pacofsky et al (1998) Potent dipeptide inhibitors of the pp60c-src SH2 domain. J.Med.Chem. 41 1894 PMID: 9599239

Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360

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Keywords: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu supplier, Phosphopeptide, ligands, SH2, domain, Src, Kinases, 1927, Tocris Bioscience

Citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

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Currently there are no citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu.

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