Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.
(Modifications: Tyr-1 = pTyr with C-terminal Ac)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Gilmer et al (1994) Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 269 31711 PMID: 7527393
Pacofsky et al (1998) Potent dipeptide inhibitors of the pp60c-src SH2 domain. J.Med.Chem. 41 1894 PMID: 9599239
Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360
If you know of a relevant reference for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, please let us know.
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Keywords: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu supplier, Phosphopeptide, ligands, SH2, domain, Src, Kinases, 1927, Tocris Bioscience
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