N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Discontinued Product

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Cat. No. 1927) has been withdrawn from sale for commercial reasons.
Description: Phosphopeptide ligand for src SH2 domain
Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu is a phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.

Technical Data

M. Wt 803.71
Formula C32H46N5O17P
Sequence YEEIE

(Modifications: Tyr-1 = pTyr with C-terminal Ac)

Storage Desiccate at -20°C
CAS Number 159439-02-8
PubChem ID 42628614
InChI Key QQEKQSBIEKQXQS-PSCZMIBCSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Safety Datasheet is currently unavailable on-line.
Please contact Customer Service.

References

References are publications that support the biological activity of the product.

Gilmer et al (1994) Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 269 31711 PMID: 7527393

Pacofsky et al (1998) Potent dipeptide inhibitors of the pp60c-src SH2 domain. J.Med.Chem. 41 1894 PMID: 9599239

Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360

View Related Products by Target

View Related Products by Product Action

View all Src Kinase Ligands

Keywords: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu supplier, Phosphopeptide, ligands, SH2, domain, Src, Kinases, 1927, Tocris Bioscience

Citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Citations are publications that use Tocris products.

Currently there are no citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu.

Reviews for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

There are currently no reviews for this product. Be the first to review N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu and earn rewards!

Have you used N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis