N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

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Cat.No. 1927 - N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu | Ac-pTyr-Glu-Glu-Ile-Glu | CAS No. 159439-02-8
Description: Phosphopeptide ligand for src SH2 domain
Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Datasheet
Citations
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Literature

Biological Activity

Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.

Technical Data

M. Wt 803.71
Formula C32H46N5O17P
Sequence YEEIE

(Modifications: Tyr-1 = pTyr with C-terminal Ac)

Storage Desiccate at -20°C
CAS Number 159439-02-8
PubChem ID 42628614
InChI Key QQEKQSBIEKQXQS-PSCZMIBCSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 803.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.24 mL 6.22 mL 12.44 mL
5 mM 0.25 mL 1.24 mL 2.49 mL
10 mM 0.12 mL 0.62 mL 1.24 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gilmer et al (1994) Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 269 31711 PMID: 7527393

Pacofsky et al (1998) Potent dipeptide inhibitors of the pp60c-src SH2 domain. J.Med.Chem. 41 1894 PMID: 9599239

Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360


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Keywords: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, supplier, Phosphopeptide, ligands, SH2, domain, Src, Kinases, Src, Kinases, Src, Kinases, Tocris Bioscience

Citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

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