Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewN-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
Discontinued Product
N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Cat. No. 1927) has been withdrawn from sale for commercial reasons.
Description: Phosphopeptide ligand for src SH2 domain
Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Biological Activity
N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu is a phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.
Technical Data
| M. Wt | 803.71 |
| Formula | C32H46N5O17P |
| Sequence |
YEEIE (Modifications: Tyr-1 = pTyr with C-terminal Ac) |
| Storage | Desiccate at -20°C |
| CAS Number | 159439-02-8 |
| PubChem ID | 42628614 |
| InChI Key | QQEKQSBIEKQXQS-PSCZMIBCSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
Safety Datasheet is currently unavailable on-line.
Please contact Customer Service.
Please contact Customer Service.
References
References are publications that support the biological activity of the product.
Gilmer et al (1994) Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 269 31711 PMID: 7527393
Pacofsky et al (1998) Potent dipeptide inhibitors of the pp60c-src SH2 domain. J.Med.Chem. 41 1894 PMID: 9599239
Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360
View Related Products by Target
View Related Products by Product Action
Keywords: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu supplier, Phosphopeptide, ligands, SH2, domain, Src, Kinases, 1927, Tocris Bioscience
Citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
Citations are publications that use Tocris products.
Currently there are no citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu.
Reviews for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
There are currently no reviews for this product. Be the first to review N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu and earn rewards!
Have you used N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Immunology Product Listing
A collection of over 190 products for immunology research, the guide includes research tools for the study of:
- Chemokine and Cytokine Signaling
- Chemotaxis
- Complement System
- Immune Cell Signaling
- Inflammation
Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases