Cabergoline

Pricing Availability Delivery Time Qty
Cat.No. 2664 - Cabergoline | C26H37N5O2 | CAS No. 81409-90-7
Description: Selective D2-like agonist
Chemical Name: N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective D2-like dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM for D2, D3, D4 and D5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (Ki = 1.2 - 20.0 nM for 5-HT1A, 5-HT1D, 5-HT2A and 5-HT2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.

Compound Libraries

Cabergoline is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 451.6
Formula C26H37N5O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 81409-90-7
PubChem ID 90488776
InChI Key MNDMRWBGBXWMDE-YPAWHYETSA-N
Smiles CC2=C(C(C[C@]3([H])[C@@]([H])2C[C@@H]([C@@](N(C(NCC)=O)CCCN(C)C)=O)CN3CC=C)=CN1)/C/1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 4.51 10
DMSO 45.16 100
ethanol 45.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 451.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.07 mL 22.14 mL
5 mM 0.44 mL 2.21 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Eguchi et al (1995) Effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 42 413 PMID: 7670571

Kvernmo et al (2006) A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin.Ther. 28 1065 PMID: 16982285

Hadj Tahar et al (2000) Sustained cabergoline treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol. 23 195 PMID:


If you know of a relevant reference for Cabergoline, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Non-selective Dopamine Agonists

Keywords: Selective D2-like agonists Dopamine Non-Selective Receptors dopaminergic Non-selective Dopamine

2 Citations for Cabergoline

Citations are publications that use Tocris products. Selected citations for Cabergoline include:

Lin et al (2015) Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline. PLoS One 6 39329 PMID: 26513171

Odaka et al (2014) Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. J Biol Chem 9 e99271 PMID: 24914776


Do you know of a great paper that uses Cabergoline from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Pathways for Cabergoline

Protocols

TODO: Add Protocols