Cabergoline

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Cat.No. 2664 - Cabergoline | C26H37N5O2 | CAS No. 81409-90-7
Description: D2-like agonist (D2>D3>D4)
Chemical Name: N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (5)

Biological Activity

Selective D2-like dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM for D2, D3, D4 and D5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (Ki = 1.2 - 20.0 nM for 5-HT1A, 5-HT1D, 5-HT2A and 5-HT2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.

Compound Libraries

Cabergoline is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 451.6
Formula C26H37N5O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 81409-90-7
PubChem ID 90488776
InChI Key MNDMRWBGBXWMDE-YPAWHYETSA-N
Smiles CC2=C(C(C[C@]3([H])[C@@]([H])2C[C@@H]([C@@](N(C(NCC)=O)CCCN(C)C)=O)CN3CC=C)=CN1)/C/1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.16 100
ethanol 45.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 451.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.07 mL 22.14 mL
5 mM 0.44 mL 2.21 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Eguchi et al (1995) Effect of cabergoline, a DA agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 42 413 PMID: 7670571

Kvernmo et al (2006) A review of the receptor-binding and pharmacokinetic properties of DA agonists. Clin.Ther. 28 1065 PMID: 16982285

Hadj Tahar et al (2000) Sustained caberg. treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol. 23 195


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Keywords: Cabergoline, Cabergoline supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, Non-selective, 2664, Tocris Bioscience

4 Citations for Cabergoline

Citations are publications that use Tocris products. Selected citations for Cabergoline include:

Leng et al (2017) Activation of DRD5 inhibits tumor growth by autophagic cell death. Autophagy 13 1404 PMID: 28613975

Lin et al (2015) Suppression of mTOR pathway and induction of autophagy-dependent cell death by caberg. PLoS One 6 39329 PMID: 26513171

Gao et al (2017) Expression of Stem Cell Markers and DA D2 Receptors in Human and Rat Prolactinomas. Med Sci Monit 23 1827 PMID: 28411401

Odaka et al (2014) Cabergoline, DA D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. J Biol Chem 9 e99271 PMID: 24914776


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Reviews for Cabergoline

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

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