C 87

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Cat.No. 5484 - C 87 | C24H15ClN6O3S | CAS No. 332420-90-3
Description: TNF-α inhibitor
Chemical Name: 3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

TNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.

Technical Data

M. Wt 502.93
Formula C24H15ClN6O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 332420-90-3
PubChem ID 5756872
InChI Key VELQTEBILFDDQX-SLMZUGIISA-N
Smiles O=C1N(C4=NC(C5=CC=CC=C5)=CS4)N=C(C3=CC=CC=C3)/C1=N/NC2=CC([N+]([O-])=O)=C(Cl)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.06 20

Preparing Stock Solutions

The following data is based on the product molecular weight 502.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.94 mL 49.71 mL 99.42 mL
1 mM 1.99 mL 9.94 mL 19.88 mL
2 mM 0.99 mL 4.97 mL 9.94 mL
10 mM 0.2 mL 0.99 mL 1.99 mL

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References

References are publications that support the biological activity of the product.

Ma et al (2014) A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 289 12457 PMID: 24634219


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Keywords: C 87, C 87 supplier, TNF-alpha, TNF-a, TNF-α, tumor, necrosis, factor, inflammation, inhibitors, C87, 1609281-56-2, inhibits, Cytokines, 5484, Tocris Bioscience

Citations for C 87

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Works Well.
By Purnima Gupta on 01/10/2018
Assay Type: In Vitro
Species: Mouse

Used in Fibroblast cytotoxicity assay


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