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Biological Activity for C 87
C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.
Technical Data for C 87
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for C 87
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for C 87
The following data is based on the product molecular weight 502.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.94 mL||49.71 mL||99.42 mL|
|1 mM||1.99 mL||9.94 mL||19.88 mL|
|2 mM||0.99 mL||4.97 mL||9.94 mL|
|10 mM||0.2 mL||0.99 mL||1.99 mL|
References for C 87
References are publications that support the biological activity of the product.
Ma et al (2014) A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 289 12457 PMID: 24634219
If you know of a relevant reference for C 87, please let us know.
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Keywords: C 87, C 87 supplier, TNF-alpha, TNF-a, TNF-α, tumor, necrosis, factor, inflammation, inhibitors, C87, 1609281-56-2, inhibits, Cytokines, 5484, Tocris Bioscience
2 Citations for C 87
Citations are publications that use Tocris products. Selected citations for C 87 include:
Minsoo et al (2019) Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Cell Rep 28 2923-2938.e8 PMID: 31509752
Markus et al (2019) Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization. J Biol Chem 294 4368-4380 PMID: 30670595
Do you know of a great paper that uses C 87 from Tocris? Please let us know.
Reviews for C 87
Average Rating: 4.5 (Based on 2 Reviews.)
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Combinatorial treatments of the TNF-alpha inhibitor with chemotherapeutics led to synergistic apoptotic phenotype in vitro.
Used in Fibroblast cytotoxicity assay
Literature in this Area
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