C 87

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Description: TNF-α inhibitor
Chemical Name: 3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews (2)
Literature (1)

Biological Activity for C 87

C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.

Technical Data for C 87

M. Wt 502.93
Formula C24H15ClN6O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 332420-90-3
PubChem ID 5756872
InChI Key VELQTEBILFDDQX-SLMZUGIISA-N
Smiles O=C1N(C4=NC(C5=CC=CC=C5)=CS4)N=C(C3=CC=CC=C3)/C1=N/NC2=CC([N+]([O-])=O)=C(Cl)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C 87

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.06 20

Preparing Stock Solutions for C 87

The following data is based on the product molecular weight 502.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.94 mL 49.71 mL 99.42 mL
1 mM 1.99 mL 9.94 mL 19.88 mL
2 mM 0.99 mL 4.97 mL 9.94 mL
10 mM 0.2 mL 0.99 mL 1.99 mL

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References for C 87

References are publications that support the biological activity of the product.

Ma et al (2014) A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 289 12457 PMID: 24634219


If you know of a relevant reference for C 87, please let us know.

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Keywords: C 87, C 87 supplier, TNF-alpha, TNF-a, TNF-α, tumor, necrosis, factor, inflammation, inhibitors, C87, 1609281-56-2, inhibits, Cytokines, 5484, Tocris Bioscience

2 Citations for C 87

Citations are publications that use Tocris products. Selected citations for C 87 include:

Minsoo et al (2019) Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Cell Rep 28 2923-2938.e8 PMID: 31509752

Markus et al (2019) Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization. J Biol Chem 294 4368-4380 PMID: 30670595


Do you know of a great paper that uses C 87 from Tocris? Please let us know.

Reviews for C 87

Average Rating: 4.5 (Based on 2 Reviews.)

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Combinatorial treatments.
By MARINA KOUTSIOUMPA on 10/13/2022
Assay Type: In Vitro
Species: Human

Combinatorial treatments of the TNF-alpha inhibitor with chemotherapeutics led to synergistic apoptotic phenotype in vitro.


Works Well..
By Purnima Gupta on 01/10/2018
Assay Type: In Vitro
Species: Mouse

Used in Fibroblast cytotoxicity assay


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.