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Biological Activity for C 87
C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.
Technical Data for C 87
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for C 87
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for C 87
The following data is based on the product molecular weight 502.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.94 mL||49.71 mL||99.42 mL|
|1 mM||1.99 mL||9.94 mL||19.88 mL|
|2 mM||0.99 mL||4.97 mL||9.94 mL|
|10 mM||0.2 mL||0.99 mL||1.99 mL|
References for C 87
References are publications that support the biological activity of the product.
Ma et al (2014) A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 289 12457 PMID: 24634219
If you know of a relevant reference for C 87, please let us know.
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Keywords: C 87, C 87 supplier, TNF-alpha, TNF-a, TNF-α, tumor, necrosis, factor, inflammation, inhibitors, C87, 1609281-56-2, inhibits, Cytokines, 5484, Tocris Bioscience
Citations for C 87
Citations are publications that use Tocris products.
Currently there are no citations for C 87. Do you know of a great paper that uses C 87 from Tocris? Please let us know.
Reviews for C 87
Average Rating: 4 (Based on 1 Review.)
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Used in Fibroblast cytotoxicity assay
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.