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Protein kinase inhibitor. Inhibits PKG, PKA and PKC (IC50 values are 4, 8 and 12 μM, respectively). Widely used as a ROCK inhibitor. Increases efficiency of human fibroblast reprogramming with PD 0325901 (Cat.No 4192), CHIR 99021 (Cat.No 4432), A 83-01 (Cat.No 2939) and hLIF. Improves survival of human pluripotent stem cells in culture.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 277.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.61 mL||18.03 mL||36.06 mL|
|5 mM||0.72 mL||3.61 mL||7.21 mL|
|10 mM||0.36 mL||1.8 mL||3.61 mL|
|50 mM||0.07 mL||0.36 mL||0.72 mL|
References are publications that support the biological activity of the product.
Gerard et al (1986) Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidation metabolism by various agonists. J.Clin.Invest. 77 61 PMID: 3003155
Yu et al (2011) Efficient feeder-free episomal reprogramming with small molecules. PLoS.One. 6 e17557 PMID: 21390254
Chen et al (2011) Chemically defined conditions for human iPSC derivation and culture. Nat.Methods 8 424 PMID: 21478862
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Keywords: C-1, C-1 supplier, Protein, kinase, C, A, G, inhibitors, inhibits, PKC, Kinases, vasodilator, HA-100, PKG, PKA, HA, 100, Broad, Spectrum, Kinase, Inhibitors, Stem, Cell, Reprogramming, 0543, Tocris Bioscience
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