You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Protein kinase inhibitor. Inhibits PKG, PKA and PKC (IC50 values are 4, 8 and 12 µM, respectively). Widely used as a ROCK inhibitor. Increases efficiency of human fibroblast reprogramming with PD 0325901 (Cat.No 4192), CHIR 99021 (Cat.No 4432), A 83-01 (Cat.No 2939) and hLIF. Improves survival of human pluripotent stem cells in culture.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 277.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.61 mL||18.03 mL||36.06 mL|
|5 mM||0.72 mL||3.61 mL||7.21 mL|
|10 mM||0.36 mL||1.8 mL||3.61 mL|
|50 mM||0.07 mL||0.36 mL||0.72 mL|
References are publications that support the biological activity of the product.
Gerard et al (1986) Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidation metabolism by various agonists. J.Clin.Invest. 77 61 PMID: 3003155
Yu et al (2011) Efficient feeder-free episomal reprogramming with small molecules. PLoS.One. 6 e17557 PMID: 21390254
Chen et al (2011) Chemically defined conditions for human iPSC derivation and culture. Nat.Methods 8 424 PMID: 21478862
If you know of a relevant reference for C-1, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: C-1, C-1 supplier, Protein, kinase, C, A, G, inhibitors, inhibits, PKC, Kinases, vasodilator, HA-100, PKG, PKA, HA, 100, Broad, Spectrum, Kinase, Inhibitors, Stem, Cell, Reprogramming, 0543, Tocris Bioscience
Citations for C-1
Citations are publications that use Tocris products.
Currently there are no citations for C-1. Do you know of a great paper that uses C-1 from Tocris? Please let us know.
Reviews for C-1
There are currently no reviews for this product. Be the first to review C-1 and earn rewards!
Have you used C-1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.