Buprenorphine hydrochloride

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Cat.No. 2808 - Buprenorphine hydrochloride | C29H41NO4.HCl | CAS No. 53152-21-9
Description: Opioid receptor ligand
Chemical Name: [5α,7α(S)]-17-(Cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

ORL1 receptor agonist that also displays mixed antagonist/partial agonist activity at κ, δ and μ-opioid receptors.

Technical Data

M. Wt 504.1
Formula C29H41NO4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53152-21-9
PubChem ID 9848989
Smiles OC1=CC=C3C2=C1O[C@@H]([C@@]7(OC)[C@]([C@@](C)(C(C)(C)C)O)([H])C4)[C@]52[C@@]4(CC7)[C@H](N(CC6CC6)CC5)C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 25.2 50
water 12.6 25

Preparing Stock Solutions

The following data is based on the product molecular weight 504.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.92 mL 19.84 mL
5 mM 0.4 mL 1.98 mL 3.97 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Wnendt et al (1999) Agonist effect of buprenorphine in a nociceptin/OFQ receptor-triggered reporter gene assay. Mol.Pharmacol. 56 334 PMID: 10419552

Tzschentke (2002) Behavioral pharmacology of buprenorphine, with a focus on preclinical models of reward and addiction. Psychopharmacology 161 1 PMID: 11967625

If you know of a relevant reference for Buprenorphine hydrochloride, please let us know.

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Keywords: Buprenorphine hydrochloride, supplier, Opioids, receptors, ligands, Receptors, Miscellaneous/Non-selective, Opioids, Miscellaneous/Non-selective, Opioids, Tocris Bioscience

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