Buprenorphine hydrochloride

Discontinued Product

Buprenorphine hydrochloride (Cat. No. 2808) has been withdrawn from sale for commercial reasons.
Description: NOP agonist; also displays mixed action δ, κ and μ receptors
Chemical Name: [5α,7α(S)]-17-(Cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Buprenorphine hydrochloride

Buprenorphine hydrochloride is a ORL1 receptor agonist that also displays mixed antagonist/partial agonist activity at κ, δ and μ-opioid receptors.

Technical Data for Buprenorphine hydrochloride

M. Wt 504.1
Formula C29H41NO4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53152-21-9
PubChem ID 9848989
Smiles OC1=CC=C3C2=C1O[C@@H]([C@@]7(OC)[C@]([C@@](C)(C(C)(C)C)O)([H])C4)[C@]52[C@@]4(CC7)[C@H](N(CC6CC6)CC5)C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Buprenorphine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Buprenorphine hydrochloride

References are publications that support the biological activity of the product.

Wnendt et al (1999) Agonist effect of Bupren. in a nociceptin/OFQ receptor-triggered reporter gene assay. Mol.Pharmacol. 56 334 PMID: 10419552

Tzschentke (2002) Behavioral pharmacology of Bupren., with a focus on preclinical models of reward and addiction. Psychopharmacology 161 1 PMID: 11967625

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Keywords: Buprenorphine hydrochloride, Buprenorphine hydrochloride supplier, Opioids, receptors, ligands, Receptors, Miscellaneous/Non-selective, NOP, 2808, Tocris Bioscience

1 Citation for Buprenorphine hydrochloride

Citations are publications that use Tocris products. Selected citations for Buprenorphine hydrochloride include:

Vidal et al (2016) Cell-Autonomous Regulation of Dendritic Spine Density by PirB. Eneuro 3 PMID: 27752542

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.