Buprenorphine hydrochloride

Pricing Availability   Qty
Description: NOP agonist; also displays mixed action δ, κ and μ receptors
Chemical Name: [5α,7α(S)]-17-(Cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (5)

Biological Activity for Buprenorphine hydrochloride

Buprenorphine hydrochloride is a ORL1 receptor agonist that also displays mixed antagonist/partial agonist activity at κ, δ and μ-opioid receptors.

Technical Data for Buprenorphine hydrochloride

M. Wt 504.1
Formula C29H41NO4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53152-21-9
PubChem ID 9848989
Smiles OC1=CC=C3C2=C1O[C@@H]([C@@]7(OC)[C@]([C@@](C)(C(C)(C)C)O)([H])C4)[C@]52[C@@]4(CC7)[C@H](N(CC6CC6)CC5)C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Buprenorphine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 12.6 25
ethanol 25.2 50

Preparing Stock Solutions for Buprenorphine hydrochloride

The following data is based on the product molecular weight 504.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.97 mL 19.84 mL 39.67 mL
2.5 mM 0.79 mL 3.97 mL 7.93 mL
5 mM 0.4 mL 1.98 mL 3.97 mL
25 mM 0.08 mL 0.4 mL 0.79 mL

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Product Datasheets for Buprenorphine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Buprenorphine hydrochloride

References are publications that support the biological activity of the product.

Wnendt et al (1999) Agonist effect of Bupren. in a nociceptin/OFQ receptor-triggered reporter gene assay. Mol.Pharmacol. 56 334 PMID: 10419552

Tzschentke (2002) Behavioral pharmacology of Bupren., with a focus on preclinical models of reward and addiction. Psychopharmacology 161 1 PMID: 11967625

If you know of a relevant reference for Buprenorphine hydrochloride, please let us know.

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Keywords: Buprenorphine hydrochloride, Buprenorphine hydrochloride supplier, Opioids, receptors, ligands, Receptors, Miscellaneous/Non-selective, NOP, 2808, Tocris Bioscience

1 Citation for Buprenorphine hydrochloride

Citations are publications that use Tocris products. Selected citations for Buprenorphine hydrochloride include:

Vidal et al (2016) Cell-Autonomous Regulation of Dendritic Spine Density by PirB. Eneuro 3 PMID: 27752542

Do you know of a great paper that uses Buprenorphine hydrochloride from Tocris? Please let us know.

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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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