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ORL1 receptor agonist that also displays mixed antagonist/partial agonist activity at κ, δ and μ-opioid receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 504.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.97 mL||19.84 mL||39.67 mL|
|2.5 mM||0.79 mL||3.97 mL||7.93 mL|
|5 mM||0.4 mL||1.98 mL||3.97 mL|
|25 mM||0.08 mL||0.4 mL||0.79 mL|
References are publications that support the biological activity of the product.
Wnendt et al (1999) Agonist effect of Bupren. in a nociceptin/OFQ receptor-triggered reporter gene assay. Mol.Pharmacol. 56 334 PMID: 10419552
Tzschentke (2002) Behavioral pharmacology of Bupren., with a focus on preclinical models of reward and addiction. Psychopharmacology 161 1 PMID: 11967625
If you know of a relevant reference for Buprenorphine hydrochloride, please let us know.
Keywords: Buprenorphine hydrochloride, Buprenorphine hydrochloride supplier, Opioids, receptors, ligands, Receptors, Miscellaneous/Non-selective, NOP, 2808, Tocris Bioscience
1 Citation for Buprenorphine hydrochloride
Citations are publications that use Tocris products. Selected citations for Buprenorphine hydrochloride include:
Vidal et al (2016) Cell-Autonomous Regulation of Dendritic Spine Density by PirB. Eneuro 3 PMID: 27752542
Do you know of a great paper that uses Buprenorphine hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.