Bumetanide

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Cat.No. 3108 - Bumetanide | C17H20N2O5S | CAS No. 28395-03-1
Description: Na+/2Cl-/K+ (NKCC) symporter inhibitor
Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (12)
Reviews
Literature (1)

Biological Activity

Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).

Compound Libraries

Bumetanide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 364.42
Formula C17H20N2O5S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 28395-03-1
PubChem ID 2471
InChI Key MAEIEVLCKWDQJH-UHFFFAOYSA-N
Smiles CCCCNC1=CC(C(O)=O)=CC(S(=O)(N)=O)=C1OC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.44 100
ethanol 27.33 75

Preparing Stock Solutions

The following data is based on the product molecular weight 364.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

O'Grady et al (1987) Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. Am.J.Physiol. 253 C177 PMID: 3303961

Isenring and Forbush (1997) Ion and bumet. binding by the Na-K-Cl cotransporter. J.Biol.Chem. 272 24556 PMID: 9305921

Morita et al (1999) Functional evidence for involvement of bumetanide-sensitive Na+K+2Cl- cotransport in the hepatoportal Na+ receptor of the sprague-dawley rat. Neurosci.Letts. 264 65


If you know of a relevant reference for Bumetanide, please let us know.

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Keywords: Bumetanide, Bumetanide supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporter, inhibitors, inhibits, Sodium, Potassium, Chloride, Cotransporters, Ion, Pumps, Na+/K+/Cl-, Symporter, 3108, Tocris Bioscience

12 Citations for Bumetanide

Citations are publications that use Tocris products. Selected citations for Bumetanide include:

Babola et al (2020) Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. Elife 9 e52160 PMID: 31913121

Alfonsa et al (2016) Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons Nature Communications 7 13495 PMID: 27853135

Angelantonio et al (2014) A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell Death Dis 5 e1501 PMID: 25356870

Bhandage et al (2019) Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling. Front Cell Infect Microbiol 9 73 PMID: 30949457


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Literature in this Area

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