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Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 364.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.74 mL||13.72 mL||27.44 mL|
|5 mM||0.55 mL||2.74 mL||5.49 mL|
|10 mM||0.27 mL||1.37 mL||2.74 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References are publications that support the biological activity of the product.
O'Grady et al (1987) Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. Am.J.Physiol. 253 C177 PMID: 3303961
Isenring and Forbush (1997) Ion and bumet. binding by the Na-K-Cl cotransporter. J.Biol.Chem. 272 24556 PMID: 9305921
Morita et al (1999) Functional evidence for involvement of bumetanide-sensitive Na+K+2Cl- cotransport in the hepatoportal Na+ receptor of the sprague-dawley rat. Neurosci.Letts. 264 65
If you know of a relevant reference for Bumetanide, please let us know.
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Keywords: Bumetanide, Bumetanide supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporter, inhibitors, inhibits, Sodium, Potassium, Chloride, Cotransporters, Ion, Pumps, Na+/K+/Cl-, Symporter, 3108, Tocris Bioscience
10 Citations for Bumetanide
Citations are publications that use Tocris products. Selected citations for Bumetanide include:
Spoljaric et al (2019) KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice. Cell Rep 26 1073 PMID: 30699338
Shulga et al (2008) Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. J Neurosci 28 6996 PMID: 18596173
Safiulina et al (2008) Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. J Physiol 586 5437 PMID: 18801845
Choe et al (2015) High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Mol Brain 85 549 PMID: 25619659
Pál et al (2015) Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Neuron 8 35 PMID: 26043770
Angelantonio et al (2014) A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell Death Dis 5 e1501 PMID: 25356870
Alfonsa et al (2016) Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons Nature Communications 7 13495 PMID: 27853135
Deeb et al (2013) Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states. Eur J Neurosci 38 2453 PMID: 23627375
Haam et al (2012) GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci 32 572 PMID: 22238092
Shulga et al (2012) The loop diuretic bumet. blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci 32 1757 PMID: 22302815
Do you know of a great paper that uses Bumetanide from Tocris? Please let us know.
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