Bumetanide

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Cat.No. 3108 - Bumetanide | C17H20N2O5S | CAS No. 28395-03-1
Description: Na+/2Cl-/K+ (NKCC) symporter inhibitor
Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Reviews
Literature

Biological Activity

Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).

Compound Libraries

Bumetanide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 364.42
Formula C17H20N2O5S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 28395-03-1
PubChem ID 2471
InChI Key MAEIEVLCKWDQJH-UHFFFAOYSA-N
Smiles CCCCNC1=CC(C(O)=O)=CC(S(=O)(N)=O)=C1OC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.44 100
ethanol 27.33 75

Preparing Stock Solutions

The following data is based on the product molecular weight 364.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

O'Grady et al (1987) Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. Am.J.Physiol. 253 C177 PMID: 3303961

Isenring and Forbush (1997) Ion and bumet. binding by the Na-K-Cl cotransporter. J.Biol.Chem. 272 24556 PMID: 9305921

Morita et al (1999) Functional evidence for involvement of bumetanide-sensitive Na+K+2Cl- cotransport in the hepatoportal Na+ receptor of the sprague-dawley rat. Neurosci.Letts. 264 65


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Keywords: Bumetanide, Bumetanide supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporter, inhibitors, inhibits, Sodium, Potassium, Chloride, Cotransporters, Ion, Pumps, Na+/K+/Cl-, Symporter, 3108, Tocris Bioscience

9 Citations for Bumetanide

Citations are publications that use Tocris products. Selected citations for Bumetanide include:

Choe et al (2015) High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Mol Brain 85 549 PMID: 25619659

Pál et al (2015) Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Neuron 8 35 PMID: 26043770

Shulga et al (2008) Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. J Neurosci 28 6996 PMID: 18596173

Safiulina et al (2008) Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. J Physiol 586 5437 PMID: 18801845

Alfonsa et al (2016) Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons Nature Communications 7 13495 PMID: 27853135

Angelantonio et al (2014) A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell Death Dis 5 e1501 PMID: 25356870

Deeb et al (2013) Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states. Eur J Neurosci 38 2453 PMID: 23627375

Haam et al (2012) GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci 32 572 PMID: 22238092

Shulga et al (2012) The loop diuretic bumet. blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci 32 1757 PMID: 22302815


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Literature in this Area

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