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Description: Selective inhibitor of skeletal muscle myosin II ATPase activity
Chemical Name: 4-Methyl-N-(phenylmethyl)benzenesulfonamide
Purity: ≥99% (HPLC)
Citations (5)

Biological Activity for BTS

BTS is a selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

Compound Libraries for BTS

BTS is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BTS

M. Wt 261.34
Formula C14H15NO2S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1576-37-0
PubChem ID 95801
Smiles CC1=CC=C(C=C1)S(=O)(=O)NCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BTS

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 18.29 70
DMSO 26.13 100

Preparing Stock Solutions for BTS

The following data is based on the product molecular weight 261.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.83 mL 19.13 mL 38.26 mL
5 mM 0.77 mL 3.83 mL 7.65 mL
10 mM 0.38 mL 1.91 mL 3.83 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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References for BTS

References are publications that support the biological activity of the product.

Cheung et al (2001) A small-molecule inhibitor of skeletal muscle myosin II. Nat.Cell.Biol. 4 83 PMID: 11744924

Ramachandran et al (2003) Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis. Cell Motil.Cytoskeleton 55 61 PMID: 12673599

Shaw et al (2003) Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry 42 6128 PMID: 12755615

If you know of a relevant reference for BTS, please let us know.

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Keywords: BTS, BTS supplier, Selective, inhibitors, inhibits, skeletal, muscle, myosin, II, ATPase, activity, Myosin, 1870, Tocris Bioscience

5 Citations for BTS

Citations are publications that use Tocris products. Selected citations for BTS include:

Ferreira et al (2018) Early redox activities modulate Xenopus tail regeneration. Nat Commun 9 4296 PMID: 30327466

Magown et al (2015) Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy. Nat Commun 6 8506 PMID: 26460719

Lee et al (2015) Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. FASEB J 5 4 PMID: 25717360

Thorne et al (2012) Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Chem Biol 19 1060 PMID: 22921073

Do you know of a great paper that uses BTS from Tocris? Please let us know.

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