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Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 261.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.83 mL||19.13 mL||38.26 mL|
|5 mM||0.77 mL||3.83 mL||7.65 mL|
|10 mM||0.38 mL||1.91 mL||3.83 mL|
|50 mM||0.08 mL||0.38 mL||0.77 mL|
References are publications that support the biological activity of the product.
Cheung et al (2001) A small-molecule inhibitor of skeletal muscle myosin II. Nat.Cell.Biol. 4 83 PMID: 11744924
Ramachandran et al (2003) Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis. Cell Motil.Cytoskeleton 55 61 PMID: 12673599
Shaw et al (2003) Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry 42 6128 PMID: 12755615
If you know of a relevant reference for BTS, please let us know.
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Keywords: BTS, BTS supplier, Selective, inhibitors, inhibits, skeletal, muscle, myosin, II, ATPase, activity, Myosin, 1870, Tocris Bioscience
5 Citations for BTS
Citations are publications that use Tocris products. Selected citations for BTS include:
Boncompagni et al (2010) The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging. Aging Cell 9 958 PMID: 20961389
Ferreira et al (2018) Early redox activities modulate Xenopus tail regeneration. Nat Commun 9 4296 PMID: 30327466
Lee et al (2015) Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. FASEB J 5 4 PMID: 25717360
Thorne et al (2012) Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Chem Biol 19 1060 PMID: 22921073
Magown et al (2015) Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy. Nat Commun 6 8506 PMID: 26460719
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Literature in this Area
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