Bryostatin 2

Description: Protein kinase C activator
Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-Tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4-octadienoic acid ester
Purity: ≥98%
Datasheet
Citations
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Biological Activity for Bryostatin 2

Protein kinase C (PKC) activator; analog of Bryostatin 1 (Cat. No. 2383). Attenuates cell proliferation and cell attachment in U937 cells. Inhibits DNA synthesis at 100 nM in SH-SY5Y human neuroblastoma cells. Also inhibits EGF binding and induces arachidonic acid release in vitro. Antitumor.

Technical Data for Bryostatin 2

M. Wt 863
Formula C45H66O16
Storage Store at -20°C
Purity ≥98%
CAS Number 87745-28-6
PubChem ID 6438131
InChI Key LIPGUSBNMQRYNL-IZBIBDMISA-N
Smiles O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: Bryostatin 2, Bryostatin 2 supplier, Protein, Kinase, C, PKC, activators, analogue, Bryostatin, 1, antitumor, macrocyclic, lactone, arachidonic, acid, release, 5237, Tocris Bioscience

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