Protein kinase C (PKC) activator; analog of Bryostatin 1 (Cat. No. 2383). Attenuates cell proliferation and cell attachment in U937 cells. Inhibits DNA synthesis at 100 nM in SH-SY5Y human neuroblastoma cells. Also inhibits EGF binding and induces arachidonic acid release in vitro. Antitumor.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in ethanol|
Preparing Stock Solutions
The following data is based on the product molecular weight 863. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.16 mL||5.79 mL||11.59 mL|
|5 mM||0.23 mL||1.16 mL||2.32 mL|
|10 mM||0.12 mL||0.58 mL||1.16 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
References are publications that support the products' biological activity.
Dale et al (1989) Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells. Cancer Res. 49 3242 PMID: 2720677
Dell'Aquila et al (1988) Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells. Cancer Res. 48 3702 PMID: 3132318
Jalava et al (1990) Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells. Cancer Res. 50 3422 PMID: 2334938
Kedei et al (2013) Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochem Pharmacol. 85 313 PMID: 23146662
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