BRD 9876

Pricing Availability Delivery Time Qty
Cat.No. 5454 - BRD 9876 | C16H14N2 | CAS No. 32703-82-5
Description: ATP non-competitive kinesin Eg5 inhibitor
Chemical Name: 6-(1,1-Dimethylethyl)-2,3-naphthalenedicarbonitrile
Purity: ≥99% (HPLC)

Biological Activity

ATP non-competitive kinesin Eg5 inhibitor. Selectively inhibits microtubule-bound Eg5. Inhibits multiple myeloma cell growth (IC50 = 2.2 μM).

Compound Libraries

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Technical Data

M. Wt 234.3
Formula C16H14N2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 32703-82-5
PubChem ID 613000
Smiles CC(C)(C)C2=CC1=CC(C#N)=C(C#N)C=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.71 50
ethanol 2.34 10mM with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 234.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.68 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Chattopadhyay et al (2015) Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitors. Cell Rep. 10 755 PMID: 25660025

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Keywords: BRD9876 ATP non-competitive kinesin-5 Eg5 inhibitors inhibits microtubule-bound Kinesin

Citations for BRD 9876

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Pathways for BRD 9876


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