BRD 9876

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Cat.No. 5454 - BRD 9876 | C16H14N2 | CAS No. 32703-82-5
Description: ATP non-competitive kinesin Eg5 inhibitor
Chemical Name: 6-(1,1-Dimethylethyl)-2,3-naphthalenedicarbonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

ATP non-competitive kinesin Eg5 inhibitor. Selectively inhibits microtubule-bound Eg5. Inhibits multiple myeloma cell growth (IC50 = 2.2 μM).

Compound Libraries

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Technical Data

M. Wt 234.3
Formula C16H14N2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 32703-82-5
PubChem ID 613000
InChI Key MKILROQBJOOZKC-UHFFFAOYSA-N
Smiles CC(C)(C)C2=CC1=CC(C#N)=C(C#N)C=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.71 50

Preparing Stock Solutions

The following data is based on the product molecular weight 234.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.54 mL 42.68 mL 85.36 mL
2.5 mM 1.71 mL 8.54 mL 17.07 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
25 mM 0.17 mL 0.85 mL 1.71 mL

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References

References are publications that support the biological activity of the product.

Chattopadhyay et al (2015) Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitors. Cell Rep. 10 755 PMID: 25660025


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Keywords: BRD 9876, BRD 9876 supplier, BRD9876, ATP, non-competitive, kinesin-5, Eg5, inhibitors, inhibits, microtubule-bound, Kinesin, Mitosis, 5454, Tocris Bioscience

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