BRD 9876

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Cat.No. 5454 - BRD 9876 | C16H14N2 | CAS No. 32703-82-5
Description: ATP non-competitive kinesin Eg5 inhibitor
Chemical Name: 6-(1,1-Dimethylethyl)-2,3-naphthalenedicarbonitrile
Purity: ≥99% (HPLC)

Biological Activity

ATP non-competitive kinesin Eg5 inhibitor. Selectively inhibits microtubule-bound Eg5. Inhibits multiple myeloma cell growth (IC50 = 2.2 μM).

Compound Libraries

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Technical Data

M. Wt 234.3
Formula C16H14N2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 32703-82-5
PubChem ID 613000
Smiles CC(C)(C)C2=CC1=CC(C#N)=C(C#N)C=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.71 50

Preparing Stock Solutions

The following data is based on the product molecular weight 234.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.54 mL 42.68 mL 85.36 mL
2.5 mM 1.71 mL 8.54 mL 17.07 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
25 mM 0.17 mL 0.85 mL 1.71 mL

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References are publications that support the biological activity of the product.

Chattopadhyay et al (2015) Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitors. Cell Rep. 10 755 PMID: 25660025

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Keywords: BRD 9876, BRD 9876 supplier, BRD9876, ATP, non-competitive, kinesin-5, Eg5, inhibitors, inhibits, microtubule-bound, Kinesin, Mitosis, 5454, Tocris Bioscience

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