Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 264.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||18.92 mL||94.58 mL||189.16 mL|
|1 mM||3.78 mL||18.92 mL||37.83 mL|
|2 mM||1.89 mL||9.46 mL||18.92 mL|
|10 mM||0.38 mL||1.89 mL||3.78 mL|
References are publications that support the biological activity of the product.
Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID: 28805801
If you know of a relevant reference for BRD 6989, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BRD 6989, BRD 6989 supplier, BRD6989, IL-10, production, enhancers, CDK8, inhibitors, enhances, inhibits, Cytokines, Cyclin-dependent, Kinase, 6438, Tocris Bioscience
Citations for BRD 6989
Citations are publications that use Tocris products.
Currently there are no citations for BRD 6989. Do you know of a great paper that uses BRD 6989 from Tocris? Please let us know.
Reviews for BRD 6989
There are currently no reviews for this product. Be the first to review BRD 6989 and earn rewards!
Have you used BRD 6989?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.