BRD 6989New
Biological Activity
Enhances IL-10 production. (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Binds and inhibits CDK8 in complex with cyclin C (IC50 of approximately 200 nM). Also inhibits CDK19 in complex with cyclin C. Increases IL-10 production in activated human and murine macrophages and dendritic cells.
Technical Data
| M. Wt | 264.33 |
| Formula | C16H16N4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 642008-81-9 |
| Smiles | CC1CCC2=NC(N)=C(C(C3=CN=CC=C3)=C2C1)C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.29 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 264.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.78 mL | 18.92 mL | 37.83 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.57 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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References
References are publications that support the biological activity of the product.
Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID: 28805801
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Keywords: BRD 6989, BRD 6989 supplier, BRD6989, IL-10, production, enhancers, CDK8, inhibitors, enhances, inhibits, Cytokines, Cyclin-dependent, Kinase, 6438, Tocris Bioscience
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