BRACO 19 trihydrochloride

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Description: Telomerase inhibitor
Chemical Name: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride
Purity: ≥94% (HPLC)

Biological Activity for BRACO 19 trihydrochloride

BRACO 19 trihydrochloride is a telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.

Technical Data for BRACO 19 trihydrochloride

M. Wt 703.14
Formula C35H43N7O2.3HCl
Storage Store at -20°C
Purity ≥94% (HPLC)
CAS Number 1177798-88-7
PubChem ID 10349800
Smiles O=C(CCN5CCCC5)NC3=CC2=NC1=CC(NC(CCN6CCCC6)=O)=CC=C1C(NC4=CC=C(N(C)C)C=C4)=C2C=C3.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRACO 19 trihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 35.16 50
DMSO 35.16 50

Preparing Stock Solutions for BRACO 19 trihydrochloride

The following data is based on the product molecular weight 703.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.84 mL 14.22 mL 28.44 mL
2.5 mM 0.57 mL 2.84 mL 5.69 mL
5 mM 0.28 mL 1.42 mL 2.84 mL
25 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets for BRACO 19 trihydrochloride

References for BRACO 19 trihydrochloride

References are publications that support the biological activity of the product.

Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID: 11961134

Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID: 15735037

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