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BRACO 19 trihydrochloride
Biological Activity for BRACO 19 trihydrochloride
BRACO 19 trihydrochloride is a telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.
Technical Data for BRACO 19 trihydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BRACO 19 trihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BRACO 19 trihydrochloride
The following data is based on the product molecular weight 703.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||2.84 mL||14.22 mL||28.44 mL|
|2.5 mM||0.57 mL||2.84 mL||5.69 mL|
|5 mM||0.28 mL||1.42 mL||2.84 mL|
|25 mM||0.06 mL||0.28 mL||0.57 mL|
Product Datasheets for BRACO 19 trihydrochloride
References for BRACO 19 trihydrochloride
References are publications that support the biological activity of the product.
Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID: 11961134
Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID: 15735037
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Citations for BRACO 19 trihydrochloride
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