BRACO 19 trihydrochloride

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Cat.No. 5312 - BRACO 19 trihydrochloride | C35H43N7O2.3HCl | CAS No. 1177798-88-7
Description: Telomerase inhibitor
Chemical Name: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.

Technical Data

M. Wt 703.14
Formula C35H43N7O2.3HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1177798-88-7
PubChem ID 10349800
InChI Key MJAPNWJRLLDPAB-UHFFFAOYSA-N
Smiles O=C(CCN5CCCC5)NC3=CC2=NC1=CC(NC(CCN6CCCC6)=O)=CC=C1C(NC4=CC=C(N(C)C)C=C4)=C2C=C3.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.16 50
water 35.16 50

Preparing Stock Solutions

The following data is based on the product molecular weight 703.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.42 mL 7.11 mL 14.22 mL
5 mM 0.28 mL 1.42 mL 2.84 mL
10 mM 0.14 mL 0.71 mL 1.42 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID: 11961134

Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID: 15735037


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Keywords: BRACO19 trihydrochloride telomerase inhibitor inhibits Telomerase

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

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